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Modified Nucleic Acids

  • Book
  • © 2016

Overview

Editors:
  1. Kazuhiko Nakatani

    1. The Institute of Scientific and Industri, Osaka University, Ibaraki, Osaka, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Yitzhak Tor

    1. University of California, San Diego, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Summarizes the latest studies in modified nucleic acid research
  • Spans various aspects of modified nucleic acids, from their chemical synthesis to the in vivo application
  • Written by internationally respected experts

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 31)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
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  2. Emissive 5-Substituted Uridine Analogues

    • Andrea Fin, Alexander R. Rovira, Patrycja A. Hopkins, Yitzhak Tor
    Pages 1-26

  3. Fluorescent Purine Nucleosides and Their Applications

    • Yoshio Saito, Azusa Suzuki, Isao Saito
    Pages 27-61

  4. Thiazole Orange-Tethered Nucleic Acids and ECHO Probes for Fluorometric Detection of Nucleic Acids

    • Akimitsu Okamoto
    Pages 63-81

  5. Synthetic Wavelength-Shifting Fluorescent Probes of Nucleic Acids

    • Christian Schwechheimer, Marcus Merkel, Peggy R. Bohländer, Hans-Achim Wagenknecht
    Pages 83-100

  6. DNA-Assisted Multichromophore Assembly

    • Tadao Takada, Mitsunobu Nakamura, Kazushige Yamana
    Pages 101-121

  7. Polymerase Synthesis of Base-Modified DNA

    • Jitka Dadová, Hana Cahová, Michal Hocek
    Pages 123-144

  8. Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications

    • Takashi Sakamoto, Kenzo Fujimoto
    Pages 145-157

  9. Site-Directed Spin Labeling for EPR Studies of Nucleic Acids

    • Sandip A. Shelke, Snorri Th. Sigurdsson
    Pages 159-187

  10. Non-covalent Modification of Double-Stranded DNA at the Mismatch and Bulged Site

    • Chikara Dohno, Kazuhiko Nakatani
    Pages 189-207

  11. 2′,4′-Bridged Nucleic Acids for Targeting Double-Stranded DNA

    • Yoshiyuki Hari, Satoshi Obika
    Pages 209-219

  12. Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-Oxoguanine

    • Shigeki Sasaki, Yosuke Taniguchi, Fumi Nagatsugi
    Pages 221-248

  13. Genetic Alphabet Expansion by Unnatural Base Pair Creation and Its Application to High-Affinity DNA Aptamers

    • Michiko Kimoto, Ken-ichiro Matsunaga, Yushi T. Redhead, Ichiro Hirao
    Pages 249-268

  14. Back Matter

    Pages 269-276
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Keywords

About this book

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Editors and Affiliations

  • The Institute of Scientific and Industri, Osaka University, Ibaraki, Osaka, Japan

    Kazuhiko Nakatani

  • University of California, San Diego, La Jolla, USA

    Yitzhak Tor

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