SpringerBriefs in Immunology

Myeloid-Derived Suppressor Cells and Cancer

Authors: Escors, D., Talmadge, J.E., Breckpot, K., Van Ginderachter, J.A., Kochan, G.

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  • Comprehensively explores the biology and role of MDSCs in cancer
  • Covers therapeutic targeting via the STAT3 pathway, a major regulatory pathway in MDSCs functions as well as in tumour cells
  • Particularly relevant for scientists working in the pharmaceutical industry and in oncology research
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eBook $54.99
price for USA in USD (gross)
  • ISBN 978-3-319-26821-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $69.99
price for USA in USD
  • ISBN 978-3-319-26819-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

Table of contents (7 chapters)

Table of contents (7 chapters)

Buy this book

eBook $54.99
price for USA in USD (gross)
  • ISBN 978-3-319-26821-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $69.99
price for USA in USD
  • ISBN 978-3-319-26819-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Myeloid-Derived Suppressor Cells and Cancer
Authors
Series Title
SpringerBriefs in Immunology
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-26821-7
DOI
10.1007/978-3-319-26821-7
Softcover ISBN
978-3-319-26819-4
Series ISSN
2194-2773
Edition Number
1
Number of Pages
IX, 102
Number of Illustrations
8 illustrations in colour
Topics