Current Topics in Microbiology and Immunology

B Cell Receptor Signaling

Editors: Kurosaki, Tomohiro, Wienands, Jürgen (Eds.)

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  • ​Discusses current models of how the B cell antigen receptor becomes activated
  • Focusses on the elucidation of intracellular B cell receptor signaling pathways  
  • Describes modulation of B cell activation by coreceptors and under disease conditions   
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  • ISBN 978-3-319-26133-1
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Hardcover $169.99
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Softcover $169.99
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  • ISBN 978-3-319-79899-8
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About this book

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

About the authors

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Assembly and Function of the Precursor B-Cell Receptor

    Übelhart, Rudolf (et al.)

    Pages 3-25

  • Receptor Dissociation and B-Cell Activation

    Yang, Jianying (et al.)

    Pages 27-43

  • Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

    Hoogeboom, Robbert (et al.)

    Pages 45-63

  • BTK Signaling in B Cell Differentiation and Autoimmunity

    Corneth, Odilia B. J. (et al.)

    Pages 67-105

  • The Memory Function of the B Cell Antigen Receptor

    Wienands, Jürgen (et al.)

    Pages 107-121

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-26133-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-26131-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-79899-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
B Cell Receptor Signaling
Editors
  • Tomohiro Kurosaki
  • Jürgen Wienands
Series Title
Current Topics in Microbiology and Immunology
Series Volume
393
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-26133-1
DOI
10.1007/978-3-319-26133-1
Hardcover ISBN
978-3-319-26131-7
Softcover ISBN
978-3-319-79899-8
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 231
Topics