Advances in Biochemistry in Health and Disease

Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Editors: Chakraborti, Sajal, Dhalla, Naranjan S (Eds.)

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  • A comprehensive investigation into the regulation of Ca2+-ATPases, F-type ATPases, and V-type ATPases
  • Explores the specific inhibitors and molecular probes for membrane ATPases to improve the therapy of various diseases
  • An informative resource to improve diverse ATPase therapeutic approaches of life threatening diseases
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eBook $169.00
price for USA in USD
  • ISBN 978-3-319-24780-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $299.99
price for USA in USD
Softcover $219.99
price for USA in USD
About this book

The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase

and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby   bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.

Table of contents (29 chapters)

Table of contents (29 chapters)
  • The Plasma Membrane Calcium ATPase: Historical Appraisal and Some New Concepts

    Pages 3-11

    Carafoli, Ernesto

  • The Plasma Membrane Ca2+ ATPases: Isoform Specificity and Functional Versatility

    Pages 13-26

    Calì, Tito (et al.)

  • PMCA2w/a Splice Variant: A Key Regulator of Hair Cell Mechano-transduction Machinery

    Pages 27-45

    Bortolozzi, Mario (et al.)

  • PMCA3: A Mysterious Isoform of Calcium Pump

    Pages 47-62

    Boczek, Tomasz (et al.)

  • The ATP2B Plasma Membrane Ca2+ ATPase Family: Regulation in Response to Changing Demands of Cellular Calcium Transport

    Pages 63-80

    Strehler, Emanuel E.

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-3-319-24780-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $299.99
price for USA in USD
Softcover $219.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Regulation of Ca2+-ATPases,V-ATPases and F-ATPases
Editors
  • Sajal Chakraborti
  • Naranjan S Dhalla
Series Title
Advances in Biochemistry in Health and Disease
Series Volume
14
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-24780-9
DOI
10.1007/978-3-319-24780-9
Hardcover ISBN
978-3-319-24778-6
Softcover ISBN
978-3-319-79677-2
Edition Number
1
Number of Pages
XIII, 586
Number of Illustrations
75 b/w illustrations, 26 illustrations in colour
Topics