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The Initiation of DNA Replication in Eukaryotes

Editors: Kaplan, Daniel L. (Ed.)

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  • ​Focus on replication initiation, a complex and highly regulated step of replication
  • Concentrate on eukaryotes, with relevance to humans and disease
  • Reveal in detail the molecular mechanisms of initiation, including protein function and regulation
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-24696-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-24694-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-79661-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur.  Errors in DNA replication can lead to genome instability and cancer.  The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process.  A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings.  The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity.  This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.   It is the cellular protein machinery that enables replication initiation to be activated and regulated.  We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

About the authors

Daniel Kaplan, PhD is an Associate Professor in the Department of Biomedical Sciences at Florida State University College of Medicine. He is the director of the Kaplan Lab that studies DNA replication and genome maintenance. Dr. Kaplan is also the Assistant Course Director for the Medical Microbiology course. Daniel Kaplan has been studying microbiology, biochemistry, and genetics for over 20 years. As an assistant professor at Vanderbilt University, Dr. Kaplan led a team that published primary research articles that investigated how DNA replication is initiated in budding yeast. As a post-doctoral fellow, Daniel Kaplan worked with National Academy of Science member Mike O’Donnell at Rockefeller University and published manuscripts on the function and mechanism of bacterial and yeast replication fork helicases. In graduate school, Daniel Kaplan worked with Nobel Laureate Thomas Steitz at Yale University to determine how the bacterial replication fork helicase, DnaB, modulates DNA structure. Dr. Kaplan attended Yale Medical School and received training in cancer research before entering graduate school.

Table of contents (26 chapters)

Table of contents (26 chapters)
  • Introduction to Eukaryotic DNA Replication Initiation

    Pages 1-21

    Dhingra, Nalini (et al.)

  • Choice of Origins and Replication Timing Control in Budding Yeast

    Pages 23-38

    Calzada, Arturo

  • Epigenetic vs. Sequence-Dependent Control of Eukaryotic Replication Timing

    Pages 39-63

    Klein, Kyle N. (et al.)

  • Up and Down the Slope: Replication Timing and Fork Directionality Gradients in Eukaryotic Genomes

    Pages 65-85

    Hyrien, Olivier

  • Chromatin Determinants of Origin Selection and Activation

    Pages 87-104

    Gutiérrez, Mónica P. (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-24696-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-24694-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-79661-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Initiation of DNA Replication in Eukaryotes
Editors
  • Daniel L. Kaplan
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-24696-3
DOI
10.1007/978-3-319-24696-3
Hardcover ISBN
978-3-319-24694-9
Softcover ISBN
978-3-319-79661-1
Edition Number
1
Number of Pages
XII, 563
Number of Illustrations
3 b/w illustrations, 84 illustrations in colour
Topics