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Current Topics in Microbiology and Immunology

Quasispecies: From Theory to Experimental Systems

Editors: Domingo, Esteban, Schuster, Peter (Eds.)

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  • Covers theoretical and experimental aspects of quasispecies
  • Includes the most recent developments in quasispecies research
  • Provides in-depth coverage of cutting-edge research in theory and experiment   ​
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About this book

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. 

About the authors

Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales. Peter Schuster, em. professor of University of Vienna is a member of Leopoldina, Nationale Akademie der Wissenschaften, National Academy of Sciences USA, European Academy of Sciences and Arts and several other institutions. He worked together with Manfred Eigen and developed together with him the concepts of "quasispecies" and "hypercycles".

Table of contents (14 chapters)

Table of contents (14 chapters)
  • What Is a Quasispecies? Historical Origins and Current Scope

    Pages 1-22

    Domingo, Esteban (et al.)

  • The Nucleation of Semantic Information in Prebiotic Matter

    Pages 23-42

    Küppers, Bernd-Olaf

  • Evolution of RNA-Based Networks

    Pages 43-59

    Stadler, Peter F.

  • Quasispecies on Fitness Landscapes

    Pages 61-120

    Schuster, Peter

  • Mathematical Models of Quasi-Species Theory and Exact Results for the Dynamics

    Pages 121-139

    Saakian, David B. (et al.)

Buy this book

eBook n/a
  • ISBN 978-3-319-23898-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-319-23897-5
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-3-319-79548-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Quasispecies: From Theory to Experimental Systems
Editors
  • Esteban Domingo
  • Peter Schuster
Series Title
Current Topics in Microbiology and Immunology
Series Volume
392
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-23898-2
DOI
10.1007/978-3-319-23898-2
Hardcover ISBN
978-3-319-23897-5
Softcover ISBN
978-3-319-79548-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 357
Number of Illustrations
14 b/w illustrations, 53 illustrations in colour
Topics