Editors:
Conjugates integrative transporter physiology, with structural and molecular biology, genetics, pharmacology and pathophysiology, offering an integration of the knowledge in these fields
Provides important information on the involvement of transporters for organic cations in determining specific effects but also side effects induced by particular drugs, offering new approaches for a successful translation from physiology to clinical therapy
Discusses the role of transporters for organic cations in plants for the environmental cycling of pharmaceutical residues
Includes supplementary material: sn.pub/extras
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (10 chapters)
-
Front Matter
-
Back Matter
About this book
This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues.
This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
Reviews
“This encyclopedic resource provides extensively detailed, state-of-the-art information about cellular organic cation transporters and their relevance to human function and disease. … This is a magnificent resource for scientists actively engaged in any research related to the biology of organic ion transporters. Every conceivable topic related to these transporters is addressed, making it useful for active researchers in a wide variety of biomedical and biological disciplines.” (David R. Bell, Doody’s Book Reviews, April, 2016)
Editors and Affiliations
-
Experimental Nephrology, MC D, University of Münste, Münster, Germany
Giuliano Ciarimboli
-
CNRS UMR8246/Inserm U1130/UPMC UMCR18/Sorbonne University, Neuroscience Institute of Biology Paris-Seine, Paris, France
Sophie Gautron
-
Experimental Nephrology, MC D, University Hospital Münste, Münster, Germany
Eberhard Schlatter
Bibliographic Information
Book Title: Organic Cation Transporters
Book Subtitle: Integration of Physiology, Pathology, and Pharmacology
Editors: Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter
DOI: https://doi.org/10.1007/978-3-319-23793-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-23792-3Published: 29 December 2015
Softcover ISBN: 978-3-319-79534-8Published: 28 March 2019
eBook ISBN: 978-3-319-23793-0Published: 17 December 2015
Edition Number: 1
Number of Pages: XV, 264
Number of Illustrations: 20 b/w illustrations, 14 illustrations in colour
Topics: Human Physiology, Pharmacology/Toxicology, Pathology