Alpha-1 Antitrypsin
Role in Health and Disease
Editors: Wanner, Adam, Sandhaus, Robert A. (Eds.)
Free Preview- Discusses issues unique to rare diseases
- Written by a group of international expert authors
- Discusses mechanisms, manifestations, and clinical outcomes
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- About this book
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This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.
- About the authors
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Adam Wanner, MD
Division of Pulmonary and Critical Care Medicine
Miller School of Medicine
University of Miami
Miami, FL, USARobert A. Sandhaus, MD, PhD
Division of Pulmonary, Critical Care, and Sleep Medicine
National Jewish Health
Denver, CO, USA
- Table of contents (9 chapters)
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Alpha-1-Antitrypsin and the Serpins
Pages 1-15
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Alpha-1 Antitrypsin: The Protein
Pages 17-30
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Misfolding and Polymerisation of Alpha1-Antitrypsin: Conformational Pathology and Therapeutic Targeting
Pages 31-52
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Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency
Pages 53-83
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United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency
Pages 85-98
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Table of contents (9 chapters)
- Download Preface 1 PDF (44.6 KB)
- Download Sample pages 1 PDF (257.1 KB)
- Download Table of contents PDF (1.4 MB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Alpha-1 Antitrypsin
- Book Subtitle
- Role in Health and Disease
- Editors
-
- Adam Wanner
- Robert A. Sandhaus
- Series Title
- Respiratory Medicine
- Copyright
- 2016
- Publisher
- Humana Press
- Copyright Holder
- Springer International Publishing Switzerland
- eBook ISBN
- 978-3-319-23449-6
- DOI
- 10.1007/978-3-319-23449-6
- Hardcover ISBN
- 978-3-319-23448-9
- Softcover ISBN
- 978-3-319-79484-6
- Series ISSN
- 2197-7372
- Edition Number
- 1
- Number of Pages
- X, 173
- Number of Illustrations
- 15 b/w illustrations, 12 illustrations in colour
- Topics
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