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Respiratory Medicine

Alpha-1 Antitrypsin

Role in Health and Disease

Editors: Wanner, Adam, Sandhaus, Robert A. (Eds.)

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  • Discusses issues unique to rare diseases
  • Written by a group of international expert authors
  • Discusses mechanisms, manifestations, and clinical outcomes
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-23449-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-23448-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-79484-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.

About the authors

Adam Wanner, MD
Division of Pulmonary and Critical Care Medicine
Miller School of Medicine
University of Miami
Miami, FL, USA

Robert A. Sandhaus, MD, PhD
Division of Pulmonary, Critical Care, and Sleep Medicine
National Jewish Health
Denver, CO, USA

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Alpha-1-Antitrypsin and the Serpins

    Pages 1-15

    Carrell, Robin

  • Alpha-1 Antitrypsin: The Protein

    Pages 17-30

    Lussier, Bethany, M.D. (et al.)

  • Misfolding and Polymerisation of Alpha1-Antitrypsin: Conformational Pathology and Therapeutic Targeting

    Pages 31-52

    Gooptu, Bibek (et al.)

  • Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency

    Pages 53-83

    Wang, Chao (et al.)

  • United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency

    Pages 85-98

    Tonelli, Adriano R., M.D. (et al.)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-23449-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-23448-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-79484-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alpha-1 Antitrypsin
Book Subtitle
Role in Health and Disease
Editors
  • Adam Wanner
  • Robert A. Sandhaus
Series Title
Respiratory Medicine
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-23449-6
DOI
10.1007/978-3-319-23449-6
Hardcover ISBN
978-3-319-23448-9
Softcover ISBN
978-3-319-79484-6
Series ISSN
2197-7372
Edition Number
1
Number of Pages
X, 173
Number of Illustrations
15 b/w illustrations, 12 illustrations in colour
Topics