Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
Editors: Miller, Daniel L., Stack, M. Sharon (Eds.)
Free Preview- Unique focus, as there is a dearth of material with a specific focus on HPV-associated oropharyngeal squamous cell carcinoma
- Topical, due to an increase of greater than 200% in cases of HPV-positive oropharyngeal cancer between 1984 and 2004
- Approaches the subject from multiple perspectives, with an emphasis on virology
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- About this book
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Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.
This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
- Table of contents (13 chapters)
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Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Pages 1-23
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Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas
Pages 25-42
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Racial Disparities in Oropharyngeal Cancer
Pages 43-68
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HPV Virology: Cellular Targets of HPV Oncogenes and Transformation
Pages 69-101
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Papillomavirus Replication
Pages 103-132
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Table of contents (13 chapters)
- Download Sample pages 2 PDF (280.2 KB)
- Download Table of contents PDF (1.5 MB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
- Editors
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- Daniel L. Miller
- M. Sharon Stack
- Copyright
- 2015
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer International Publishing Switzerland
- eBook ISBN
- 978-3-319-21100-8
- DOI
- 10.1007/978-3-319-21100-8
- Hardcover ISBN
- 978-3-319-21099-5
- Softcover ISBN
- 978-3-319-35478-1
- Edition Number
- 1
- Number of Pages
- VIII, 314
- Number of Illustrations
- 7 b/w illustrations, 22 illustrations in colour
- Topics
