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Results and Problems in Cell Differentiation

Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations

Editors: Hsu, Ellen, Du Pasquier, Louis (Eds.)

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  • Provides state-of-the-art reviews on host-pathogen interactions
  • Offers comprehensive information on the immunological processes involved in pathogen defense in different organisms
  • Written by international experts from different fields
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  • ISBN 978-3-319-20819-0
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About this book

This volume provides in-depth reviews of model systems that exemplify the arms race in host-pathogen interactions. Somatic adaptations are responsible for the individualization of biological responses to the environment, and the continual struggle between host immune systems and invading pathogens has given rise to corresponding processes that produce molecular variation. Whether in mollusks or human beings, various host somatic mechanisms have evolved independently, providing responses to counter rapidly-changing pathogens. The pathways they utilize can include non-heritable changes involving RNA and post-translational modifications, or changes that produce somatic DNA recombination and mutation. For infectious organisms such as protozoans and flatworms, antigenic variation is central to their survival strategy. Evolving the ability to evade the host immune system not only increases their chances of survival but is also necessary for successful re-infection within the host population.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Evolution of Immunity and Pathogens

    Pages 1-20

    Jack, Robert S.

  • A Host–Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei

    Pages 23-46

    Hovel-Miner, Galadriel (et al.)

  • Antigenic Variation in Plasmodium falciparum

    Pages 47-90

    Petter, Michaela (et al.)

  • Polymorphic Mucin-Like Proteins in Schistosoma mansoni, a Variable Antigen and a Key Component of the Compatibility Between the Schistosome and Its Snail Host

    Pages 91-108

    Gourbal, Benjamin (et al.)

  • Fibrinogen-Related Proteins (FREPs) in Mollusks

    Pages 111-129

    Adema, Coen M.

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-20819-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-20818-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-3-319-37182-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
Editors
  • Ellen Hsu
  • Louis Du Pasquier
Series Title
Results and Problems in Cell Differentiation
Series Volume
57
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-20819-0
DOI
10.1007/978-3-319-20819-0
Hardcover ISBN
978-3-319-20818-3
Softcover ISBN
978-3-319-37182-5
Series ISSN
0080-1844
Edition Number
1
Number of Pages
VIII, 336
Topics

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