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SH Domains

Structure, Mechanisms and Applications

Editors: Kurochkina, Natalya (Ed.)

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  • ​Provides state-of-the-art review on the important roles of SH domains
  • Gives outlook on future applications in stem cell therapy and biomaterials
  • Written by international experts from the field
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eBook $109.00
price for USA in USD
  • ISBN 978-3-319-20098-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
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  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-20097-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $149.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 4, 2016
  • ISBN 978-3-319-37252-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
About this book

This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • SH3 Domains as Suitable Models to Study Amyloid Aggregation

    Pages 1-15

    Morel, Bertrand (et al.)

  • SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking

    Pages 17-33

    Zhuang, Xiaohong (et al.)

  • Versatility of SH3 Domains in the Cellular Machinery

    Pages 35-69

    Azuaga, Ana I. (et al.)

  • Structure-Function Relationship of Bacterial SH3 Domains

    Pages 71-89

    Kamitori, Shigehiro (et al.)

  • Activation of PI3K by Thyroid Hormone Nuclear Receptors

    Pages 91-110

    Park, Jeong Won (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-319-20098-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-20097-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $149.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 4, 2016
  • ISBN 978-3-319-37252-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
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Bibliographic Information

Bibliographic Information
Book Title
SH Domains
Book Subtitle
Structure, Mechanisms and Applications
Editors
  • Natalya Kurochkina
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-20098-9
DOI
10.1007/978-3-319-20098-9
Hardcover ISBN
978-3-319-20097-2
Softcover ISBN
978-3-319-37252-5
Edition Number
1
Number of Pages
VIII, 253
Number of Illustrations
22 b/w illustrations, 30 illustrations in colour
Topics