Authors:
Textbook for courses at both graduate and undergraduate level
Also for related courses in biochemistry, biochemistry lab and methods
Contains comprehensive analytical description of structure, biophysics and function of proteins
Also summarizes the techniques used to characterize protein and protein interactions
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Table of contents (18 chapters)
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Front Matter
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Proteins
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Front Matter
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Membrane Transport
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Front Matter
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About this book
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance.
This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses.
About the author:
Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Keywords
- Cell-cell interactions
- Enzyme kinetics
- Fractionisation of cells
- Hemoglobin diseases
- Homogenisation of cells
- Inactivation of enzymes
- Inhibition of enzymes
- Levinthal's paradox
- Membrane proteins
- Molecular mechanism of Serine-proteases
- Morpheeins
- Motor proteins and movement
- Multiple phosphorylation
- Prion diseases
- Protein transport across membranes
- Structure of immunoglobulins
- Transport of solutes across membranes
- Vesicular transport in eukaryotic cells
Authors and Affiliations
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Kevelaer, Germany
Engelbert Buxbaum
About the author
Bibliographic Information
Book Title: Fundamentals of Protein Structure and Function
Authors: Engelbert Buxbaum
DOI: https://doi.org/10.1007/978-3-319-19920-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-19919-1Published: 07 December 2015
Softcover ISBN: 978-3-319-79290-3Published: 21 March 2019
eBook ISBN: 978-3-319-19920-7Published: 27 November 2015
Edition Number: 2
Number of Pages: XVI, 521
Number of Illustrations: 23 b/w illustrations, 223 illustrations in colour
Topics: Biochemistry, general, Cell Biology, Chemistry/Food Science, general, Biomedicine general, Biological and Medical Physics, Biophysics