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Topics in Medicinal Chemistry

The Smoothened Receptor in Cancer and Regenerative Medicine

Editors: Ruat, Martial (Ed.)

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  • Due: November 4, 2016
  • ISBN 978-3-319-35402-6
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About this book

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Smoothened Inhibitors in Cancer

    Pages 1-11

    Ruat, Martial (et al.)

  • Canonical and Non-Canonical Hedgehog Signaling Pathways: Role of G Proteins

    Pages 13-42

    Riobo, Natalia A.

  • Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design

    Pages 43-107

    Manetti, Fabrizio (et al.)

  • Receptor Modifications in Hedgehog Regulation

    Pages 109-125

    Shi, Qing (et al.)

  • Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery

    Pages 127-146

    Rognan, Didier (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-3-319-19755-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-3-319-19754-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 4, 2016
  • ISBN 978-3-319-35402-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
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Bibliographic Information

Bibliographic Information
Book Title
The Smoothened Receptor in Cancer and Regenerative Medicine
Editors
  • Martial Ruat
Series Title
Topics in Medicinal Chemistry
Series Volume
16
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-19755-5
DOI
10.1007/978-3-319-19755-5
Hardcover ISBN
978-3-319-19754-8
Softcover ISBN
978-3-319-35402-6
Series ISSN
1862-2461
Edition Number
1
Number of Pages
VII, 210
Topics

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