Advances in Experimental Medicine and Biology

The Male Role in Pregnancy Loss and Embryo Implantation Failure

Editors: Bronson, Richard (Ed.)

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  • Summarizes the varying factors the male contributes to pregnancy loss and embryo implantation failure, beyond chromosome abnormalities present at fertilization
  • Discusses seminal plasma and spermatozoa complexity
  • Explores potential for future translational research possibilities
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  • ISBN 978-3-319-18881-2
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Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-18880-5
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Softcover $159.99
price for USA in USD
  • ISBN 978-3-319-35698-3
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About this book

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

About the authors

Dr. Bronson is Professor of Obstetrics & Gynecology and Pathology and Director of Division of Reproductive Endocrinology and the Andrology Laboratory at Stony Brook University Medical Center. While at North Shore University Medical Center, Dr. Bronson and his associates developed an assay to detect the presence of antibodies on human spermatozoa, which is now in world-wide use. He has been active in the American Society of Reproductive Immunology, becoming its President in 1990 and currently serves on its Council. Bronson has served on the editorial boards of the Journal of Reproductive Immunology, the Journal of Andrology, The Pharos, have been an Associate Editor of Human Reproduction and the Editor-in-Chief of the textbook Reproductive Immunology, published by Blackwell. Bronson has been post graduate course director for the American Society of Reproductive Medicine, in 1998 and 2000 and the primary author of 80 peer reviewed papers. Dr. Bronson's recent professional activities include Co-Chairing the 31st Annual Meeting of the American Society for Reproductive Immunology the council on which he serves. He was also named to the Editorial Board of Fertility & Sterility. He is also a published poet, with his work appearing in both literary and medical journals, and two books of his collected poetry.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Meiotic Nondisjunction: Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa

    Pages 1-21

    Ioannou, Dimitrios (et al.)

  • Damage to Sperm DNA Mediated by Reactive Oxygen Species: Its Impact on Human Reproduction and the Health Trajectory of Offspring

    Pages 23-47

    Gavriliouk, Dan (et al.)

  • Small RNAs: Their Possible Roles in Reproductive Failure

    Pages 49-79

    Hale, Benjamin J. (et al.)

  • The Sperm Epigenome, Male Aging, and Potential Effects on the Embryo

    Pages 81-93

    Jenkins, Timothy G., Ph.D. (et al.)

  • The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

    Pages 95-126

    Bulmer, Judith N. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-319-18881-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-18880-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $159.99
price for USA in USD
  • ISBN 978-3-319-35698-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Male Role in Pregnancy Loss and Embryo Implantation Failure
Editors
  • Richard Bronson
Series Title
Advances in Experimental Medicine and Biology
Series Volume
868
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-18881-2
DOI
10.1007/978-3-319-18881-2
Hardcover ISBN
978-3-319-18880-5
Softcover ISBN
978-3-319-35698-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 228
Number of Illustrations
8 b/w illustrations, 12 illustrations in colour
Topics