Arterial Chemoreceptors in Physiology and Pathophysiology

1. Front Matter

   Pages i-xi

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2. Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications

   • Jayasri Nanduri, Nanduri R. Prabhakar

   Pages 1-8

3. Experimental Observations on the Biological Significance of Hydrogen Sulfide in Carotid Body Chemoreception

   • T. Gallego-Martin, T. Agapito, M. Ramirez, E. Olea, S. Yubero, A. Rocher et al.

   Pages 9-16

4. The CamKKβ Inhibitor STO609 Causes Artefacts in Calcium Imaging and Selectively Inhibits BKCa in Mouse Carotid Body Type I Cells

   • Jennifer G. Jurcsisn, Richard L. Pye, Jon Ali, Barbara L. Barr, Christopher N. Wyatt

   Pages 17-24

5. Tissue Dynamics of the Carotid Body Under Chronic Hypoxia: A Computational Study

   • Andrea Porzionato, Diego Guidolin, Veronica Macchi, Gloria Sarasin, Andrea Mazzatenta, Camillo Di Giulio et al.

   Pages 25-39

6. Paracrine Signaling in Glial-Like Type II Cells of the Rat Carotid Body

   • Sindhubarathi Murali, Min Zhang, Colin A. Nurse

   Pages 41-47

7. Selective mu and kappa Opioid Agonists Inhibit Voltage-Gated Ca2+ Entry in Isolated Neonatal Rat Carotid Body Type I Cells

   • Ellen M. Ricker, Richard L. Pye, Barbara L. Barr, Christopher N. Wyatt

   Pages 49-54

8. Measurement of ROS Levels and Membrane Potential Dynamics in the Intact Carotid Body Ex Vivo

   • Andre Bernardini, Ulf Brockmeier, Eric Metzen, Utta Berchner-Pfannschmidt, Eva Harde, Amparo Acker-Palmer et al.

   Pages 55-59

9. Acutely Administered Leptin Increases [Ca2+]i and BKCa Currents But Does Not Alter Chemosensory Behavior in Rat Carotid Body Type I Cells

   • Richard L. Pye, Eric J. Dunn, Ellen M. Ricker, Jennifer G. Jurcsisn, Barbara L. Barr, Christopher N. Wyatt

   Pages 61-67

10. Functional Properties of Mitochondria in the Type-1 Cell and Their Role in Oxygen Sensing

    • Keith J. Buckler, Philip J. Turner

    Pages 69-80

11. Potentiation of Hypoxic Pulmonary Vasoconstriction by Hydrogen Sulfide Precursors 3-Mercaptopyruvate and D-Cysteine Is Blocked by the Cystathionine γ Lyase Inhibitor Propargylglycine

    • Jesus Prieto-Lloret, Philip I. Aaronson

    Pages 81-87

12. Modulation of the LKB1-AMPK Signalling Pathway Underpins Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

    • A. Mark Evans, Sophronia A. Lewis, Oluseye A. Ogunbayo, Javier Moral-Sanz

    Pages 89-99

13. Organismal Responses to Hypoxemic Challenges

    • Robert S. Fitzgerald, Gholam A. Dehghani, Samara Kiihl

    Pages 101-113

14. Effect of Lipopolysaccharide Exposure on Structure and Function of the Carotid Body in Newborn Rats

    • Z. R. Master, K. Kesavan, A. Mason, M. Shirahata, Estelle B. Gauda

    Pages 115-121

15. Hypoxic Ventilatory Reactivity in Experimental Diabetes

    • M. Pokorski, M. Pozdzik, J. Antosiewicz, A. Dymecka, A. Mazzatenta, C. Di Giulio

    Pages 123-132

16. Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals

    • J. F. Sacramento, C. Gonzalez, M. C. Gonzalez-Martin, S. V. Conde

    Pages 133-137

17. Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body

    • Patricia Ortega-Sáenz, Javier Villadiego, Ricardo Pardal, Juan José Toledo-Aral, José López-Barneo

    Pages 139-152

18. Is the Carotid Body a Metabolic Monitor?

    • M. Shirahata, W.-Y. Tang, M.-K. Shin, V. Y. Polotsky

    Pages 153-159

19. Lipopolysaccharide-Induced Ionized Hypocalcemia and Acute Kidney Injury in Carotid Chemo/Baro-Denervated Rats

    • R. Fernández, P. Cortés, R. Del Rio, C. Acuña-Castillo, E. P. Reyes

    Pages 161-166

20. Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies

    • Harold D. Schultz, Noah J. Marcus, Rodrigo Del Rio

    Pages 167-185

Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.

• cardiorespiratory disease
• carotid body
• hypercapnia
• hypoxia
• oxygen sensing
• gene expression

• Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Faculty of Medicine and Health, Leeds, United Kingdom

  Chris Peers

• College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

  Prem Kumar

• Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, USA

  Christopher Wyatt

• Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, USA

  Estelle Gauda

• Department of Biology, McMaster University, Hamilton, Canada

  Colin A. Nurse

• Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing Biological Sciences Division, University of Chicago, Chicago, USA

  Nanduri Prabhakar

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