Resistance to Targeted Anti-Cancer Therapeutics

Resistance to Aromatase Inhibitors in Breast Cancer

Editors: Larionov, Alexey (Ed.)

  • Brings together the current knowledge of molecular and translational aspects of AIs resistance in breast cancer
  • Provides mechanisms of physiological resistance and potential biomarkers that recognize or predict mechanisms of resistance
  • Explores acquired, adjuvant, pre-operative, and metastatic resistance
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-17972-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-17971-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-38284-5
  • Free shipping for individuals worldwide
About this book

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

About the authors

Alexey Larionov, Ph.D. is a researcher at the Academic Laboratory of Medical Genetics and Statistics and Computational Biology Lab at the University of Cambridge. Dr Larionov is an expert in endocrine resistance in breast cancer, as well as whole exome sequencing data analysis. Dr. Larionov has received over 1019 citations.

Table of contents (12 chapters)

  • Clinical Use of Aromatase Inhibitors in Breast Cancer: History and Present

    Cameron, David

    Pages 1-11

  • Structure, Regulation and Polymorphisms of the Aromatase Gene

    Harada, Nobuhiro

    Pages 13-31

  • Structure, Function and Inhibition of Aromatase

    Ghosh, Debashis (et al.)

    Pages 33-61

  • In Vivo Models of AI Resistance

    Sabnis, Gauri (et al.)

    Pages 63-86

  • Ineffective Inhibition of Aromatase: A Cause for AI Resistance?

    Lønning, Per E.

    Pages 87-99

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-17972-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-17971-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-3-319-38284-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Resistance to Aromatase Inhibitors in Breast Cancer
Editors
  • Alexey Larionov
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
8
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-17972-8
DOI
10.1007/978-3-319-17972-8
Hardcover ISBN
978-3-319-17971-1
Softcover ISBN
978-3-319-38284-5
Series ISSN
2196-5501
Edition Number
1
Number of Pages
XVI, 288
Number of Illustrations
29 b/w illustrations, 27 illustrations in colour
Topics