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Advances in Experimental Medicine and Biology

Membrane Potential Imaging in the Nervous System and Heart

Editors: Canepari, Marco, Zecevic, Dejan, Bernus, Olivier (Eds.)

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  • Fully-expanded and updated Second Edition reflects all recent advances and new developments in the field 
  • Comprehensively examines applications of membrane potential imaging, from the neuronal level to larger networks in the CNS and heart
  • Carefully curated images bring the content to life, tangibly demonstrating the abilities and applications of the technology
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About this book

This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling. This is an expanded and fully-updated second edition, reflecting all the recent advances in this field.

Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs and genetically encoded voltage sensors.

Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electro physiologists, cardiologists and those who are interested in the applications and the future of membrane potential imaging.

About the authors

Marco Canepari (b. Milan 1970) is first class INSERM researcher (CR1) working at the Laboratoire Interdisciplinaire de Physique in Grenoble. He graduated in physics at the University of Genoa and received his PhD in biophysics from the International School for Advanced Studies in Trieste. He worked at the National Institute for Medical Research in London, at Yale University and at the University of Basel. Marco is expert on several optical techniques applied to neurophysiology. Marco and Dejan collaborated for a number of years using voltage-imaging and calcium imaging approaches to study mechanisms underlying synaptic plasticity.

Olivier Bernus (b. Tournai 1976) is Professor and Scientific Director at the Electrophysiology and Heart Modeling Institute LIRYC at the University of Bordeaux, France. He graduated in Mathematical Physics at the University of Ghent, Belgium and obtained his PhD in Physics from the same university. He subsequently worked as a postdoctoral fellow at SUNY Upstate Medical University, USA, and as a tenure track research fellow at the University of Leeds, UK. Olivier is an expert in cardiac optical imaging and is currently working on the development of novel techniques for three-dimensional depth-resolved optical imaging of cardiac electrical activity.

Dejan Zecevic (b. Belgrade 1948) is Senior Research Scientist at the Department of Cellular and Molecular Physiology, Yale University School of Medicine. He received the PhD in Biophysics from The University of Belgrade, Serbia and was trained in the laboratory of Dr Lawrence Cohen who initiated the field of voltage-sensitive dye recording. Dejan is the pioneer of intracellular voltage-sensitive dye imaging technique, a unique and a cutting edge technology for monitoring the membrane potential signaling in axons, dendrites and dendritic spines of individual nerve cells.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Historical Overview and General Methods of Membrane Potential Imaging

    Pages 3-26

    Braubach, Oliver (et al.)

  • Design and Use of Organic Voltage Sensitive Dyes

    Pages 27-53

    Loew, Leslie M.

  • Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines

    Pages 57-101

    Popovic, Marko (et al.)

  • Combining Membrane Potential Imaging with Other Optical Techniques

    Pages 103-125

    Jaafari, Nadia (et al.)

  • Monitoring Spiking Activity of Many Individual Neurons in Invertebrate Ganglia

    Pages 127-145

    Frost, W. N. (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-3-319-17641-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-17640-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-37144-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Membrane Potential Imaging in the Nervous System and Heart
Editors
  • Marco Canepari
  • Dejan Zecevic
  • Olivier Bernus
Series Title
Advances in Experimental Medicine and Biology
Series Volume
859
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-17641-3
DOI
10.1007/978-3-319-17641-3
Hardcover ISBN
978-3-319-17640-6
Softcover ISBN
978-3-319-37144-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XI, 516
Number of Illustrations
35 b/w illustrations, 122 illustrations in colour
Topics

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