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Diabetic Bone Disease

Basic and Translational Research and Clinical Applications

  • A comprehensive presentation of the current research and treatment for skeletal deficits and complications due to diabetes type 1 and 2

  • Covers epidemiology, fracture risk assessment, biomarkers, biomechanics, bone quality, and the safety and efficacy of anti-diabeteic therapy on bone health

  • An excellent resource for endocrinologists and orthopedists alike

  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
  2. Clinical and Pre-clinical Applications and Research

    1. Front Matter

      Pages 1-1
    2. Skeletal Deficits in Type 1 Diabetes Mellitus

      • Kathryn M. Thrailkill
      Pages 3-24
    3. Type 2 Diabetes Mellitus and Skeletal Health

      • Ann V. Schwartz
      Pages 25-43
    4. Fracture Risk Assessment in Diabetes

      • William D. Leslie, Stephen Hough
      Pages 45-69
    5. Diabetes-Related Conditions and Complications in Orthopaedic Surgery

      • Daniel J. Gehling, Nabil A. Ebraheim
      Pages 71-93
    6. Impact of Diabetes on Periodontal Disease

      • E. Xiao, Yingying Wu, Dana T. Graves
      Pages 95-112
    7. Biomarkers of Diabetic Bone Disease

      • Mishaela R. Rubin
      Pages 113-124
    8. Safety of Antidiabetic Therapies on Bone

      • Beata Lecka-Czernik, Ann V. Schwartz
      Pages 125-145
    9. Bone Marrow Stem Cells and Bone Turnover in Diabetic Disease

      • Laura R. McCabe, Sandi Raehtz, Caitlyn VanGelderen, Naiomy D. Rios-Arce
      Pages 147-179
  3. Biomechanics and Bone Quality

    1. Front Matter

      Pages 181-181
    2. Material Properties of Diabetic Bone

      • Jeffry S. Nyman, Amy Creecy
      Pages 183-210
    3. Bone Quality in Type 2 Diabetes Mellitus

      • Joshua N. Farr, Sundeep Khosla
      Pages 211-224
    4. Imaging of Diabetic Bone Structure

      • Thomas M. Link, Ursula Heilmeier
      Pages 225-236
  4. Back Matter

    Pages 237-241

About this book

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

Editors and Affiliations

  • Departments of Orthopedic Surgery, Physiology and Pharmacology, Center for Diabetes and Endocrine Research; University of Toledo, Toledo, USA

    Beata Lecka-Czernik

  • Departments of Pediatrics, Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, USA

    John L. Fowlkes

About the editors

Beata Lecka-Czernik, PhD, Professor, Department of Orthopedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Health Sciences Campus, Toledo, OH, USA

John L. Fowlkes, MD, James Hamlen Professor of Pediatrics, Vice-Chair for Research, Section Chief, Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA

Bibliographic Information

  • Book Title: Diabetic Bone Disease

  • Book Subtitle: Basic and Translational Research and Clinical Applications

  • Editors: Beata Lecka-Czernik, John L. Fowlkes

  • DOI: https://doi.org/10.1007/978-3-319-16402-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-16401-4Published: 23 October 2015

  • Softcover ISBN: 978-3-319-35374-6Published: 23 August 2016

  • eBook ISBN: 978-3-319-16402-1Published: 12 October 2015

  • Edition Number: 1

  • Number of Pages: X, 241

  • Topics: Endocrinology, Orthopedics

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access