Read While You Wait - Get immediate ebook access, if available*, when you order a print book

Springer Theses

High-Resolution Profiling of Protein-RNA Interactions

Authors: Munschauer, Mathias

Free Preview
  • Nominated as outstanding PhD thesis by Max-Delbrück Center for Molecular Medicine, Germany
  • Describes the development of a novel technology for transcriptome-wide analysis of protein-RNA interactions
  • Paves the way to future genome-wide studies of post-transcriptional gene regulatory networks
see more benefits

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-16253-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-16252-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $129.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 18, 2016
  • ISBN 978-3-319-36848-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
About this book

The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universität Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.

 

Table of contents (5 chapters)

Table of contents (5 chapters)

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-16253-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-16252-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $129.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 18, 2016
  • ISBN 978-3-319-36848-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
High-Resolution Profiling of Protein-RNA Interactions
Authors
Series Title
Springer Theses
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-16253-9
DOI
10.1007/978-3-319-16253-9
Hardcover ISBN
978-3-319-16252-2
Softcover ISBN
978-3-319-36848-1
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXIII, 121
Number of Illustrations
5 b/w illustrations, 20 illustrations in colour
Topics

*immediately available upon purchase as print book shipments may be delayed due to the COVID-19 crisis. ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. Springer Reference Works are not included.