Mathematical Modeling and Scale-Up of Liquid Chromatography

With Application Examples

Authors: Gu, Tingyue

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  • Introduces user-friendly software (with graphical user interface) and detailed descriptions on how to use the software
  • Outlines step-by-step instructions on parameter estimation for the models
  • Includes an updated literature review
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eBook $79.99
price for USA in USD
  • ISBN 978-3-319-16145-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-16144-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $99.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: April 7, 2015
  • ISBN 978-3-319-30760-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
About this book

Tingyue Gu's second edition provides a comprehensive set of nonlinear multicomponent liquid chromatography (LC) models for various forms of LC, such as adsorption, size exclusion, ion-exchange, reversed-phase, affinity, isocratic/gradient elution and axial/radial flow LC. Much has advanced since the first edition of this book and the author's software, described here, is now used for teaching and research in 32 different countries. This book comes together with a complete software package with graphical user interface for personal computers, offered free for academic applications. Additionally, this book provides detailed methods for parameter estimation of mass transfer coefficients, bed voidage, particle porosity and isotherms. The author gives examples of how to use the software for predicitons and scale-up. In contrast to the first edition, authors do not need to deal with complicated math. Instead, they focus on how to obtain a few parameters for simulation and how to compare simulation results with experimental data. After reading the detailed descriptions in the book, a reader is able to use the simulation software to investigate chromatographic behavior without doing actual experiments. This book is aimed at readers who are interested in learning about LC behaviors and at those who want to scale up LC for preparative- and large-scale applications. Both academic personnel and industrial practitioners can benefit from the use of the book. This new edition includes:
- New models and software for pellicular (cored) beads in liquid chromatography
- Introduction of user-friendly software (with graphical user interface)
- Detailed descriptions on how to use the software
- Step-by-step instructions on parameter estimation for the models
- New mass-transfer correlations for parameter estimation
- Experimental methods for parameter estimation
- Several actual examples using the model for product development and scale-up
- Updated literature review

About the authors

Dr. Tingyue Gu is a professor in the Department of Chemical & Biomolecular Engineering at Ohio University. He obtained his PhD degree in chemical engineering from Purdue University in 1990. His PhD work was devoted to liquid chromatography (LC) theories and modeling. Dr. Gu has solved a series of LC models numerically for various forms of LC and developed a comprehensive software package with graphical user interface. His software has been used in over 34 countries by numerous people. The software is offered for free for academic applications. It has also been commercially licensed by major companies including leading biotech and pharmaceutical companies. The software has been successfully used for product development with huge savings in time through simulation. Apart from LC, his current research also encompasses bioenergy, biofilm electrochemistry, biocorrosion, and microbial fuel cells.

Reviews

“This book is a welcome addition for those who want to better understand the modeling of nonlinear liquid chromatography. … The combination of this book with the Chromulator software makes this a good teaching resource for specialized undergraduate or graduate chemistry as well as chemical engineering courses. … This book is definitely written in the language of chemical engineers, but chemists and other users of chromatography will also appreciate its capacity to improve their understanding of the modeling of chromatography.” (Attila Felinger, Analytical and Bioanalytical Chemistry, April, 2016)


Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $79.99
price for USA in USD
  • ISBN 978-3-319-16145-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-16144-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $99.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: April 7, 2015
  • ISBN 978-3-319-30760-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
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Bibliographic Information

Bibliographic Information
Book Title
Mathematical Modeling and Scale-Up of Liquid Chromatography
Book Subtitle
With Application Examples
Authors
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-16145-7
DOI
10.1007/978-3-319-16145-7
Hardcover ISBN
978-3-319-16144-0
Softcover ISBN
978-3-319-30760-2
Edition Number
2
Number of Pages
XV, 207
Number of Illustrations
86 b/w illustrations, 35 illustrations in colour
Topics