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Advances in Experimental Medicine and Biology

Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

Editors: Hrycay, Eugene G., Bandiera, Stelvio M. (Eds.)

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  • This is the first book that provides up-to-date, comprehensive reviews on the monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450 enzymes in 13 chapters compiled by leading scientists in their field
  • This book is available in paper and electronic formats and will be helpful to researchers and graduate students in their areas
  • Customers should purchase this book as there are no recent books on the market that review the peroxidase and peroxygenase properties of cytochrome P450 enzymes
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-16009-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-16008-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week).
  • Due: November 18, 2016
  • ISBN 978-3-319-34794-3
  • Free shipping for individuals worldwide
About this book

This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes

    Pages 1-61

    Hrycay, Eugene G. (et al.)

  • Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants

    Pages 63-81

    Modi, Anuja R. (et al.)

  • Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions

    Pages 83-105

    Sevrioukova, Irina F. (et al.)

  • Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1

    Pages 107-130

    Akhtar, Muhammad (et al.)

  • Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates

    Pages 131-149

    Erratico, Claudio A. (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-16009-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-16008-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week).
  • Due: November 18, 2016
  • ISBN 978-3-319-34794-3
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
Editors
  • Eugene G. Hrycay
  • Stelvio M. Bandiera
Series Title
Advances in Experimental Medicine and Biology
Series Volume
851
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-16009-2
DOI
10.1007/978-3-319-16009-2
Hardcover ISBN
978-3-319-16008-5
Softcover ISBN
978-3-319-34794-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 368
Number of Illustrations
91 b/w illustrations, 59 illustrations in colour
Topics