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  • © 2015

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

Editors:

  • A timely and comprehensive overview of the latest science for perfluorinated compounds (PFCs) that fills a gap in current literature
  • Provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFCs to give readers an expert perspective on these issues
  • Emphasizes the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health

Part of the book series: Molecular and Integrative Toxicology (MOLECUL)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiii
  2. Perfluorinated Compounds: An Overview

    • Christopher Lau
    Pages 1-21
  3. PFASs in the General Population

    • Kayoko Kato, Xiaoyun Ye, Antonia M. Calafat
    Pages 51-76
  4. Perfluorinated Alkyl Acids in Wildlife

    • Jessica L. Reiner, Benjamin J. Place
    Pages 127-150
  5. Metabolism and Pharmacokinetics

    • Naomi Kudo
    Pages 151-175
  6. Metabolic Effects PFAS

    • Qixiao Jiang, Hui Gao, Lei Zhang
    Pages 177-201
  7. Developmental Toxicity

    • Barbara D. Abbott
    Pages 203-218
  8. Neurotoxicity

    • Henrik Viberg, Espen Mariussen
    Pages 219-238
  9. Immunotoxicity of Perfluoroalkylated Compounds

    • Deborah E. Keil
    Pages 239-248
  10. Effects of PFOA on Endocrine-Related Systems

    • Casey E. Reed, Suzanne E. Fenton
    Pages 249-264
  11. Carcinogenicity of Perfluoroalkyl Compounds

    • Gerald L. Kennedy, J. Morel Symons
    Pages 265-304
  12. Epidemiological Findings

    • Naila Khalil, Miryoung Lee, Kyle Steenland
    Pages 305-335
  13. Dosimetric Anchoring of Toxicological Studies

    • John Wambaugh
    Pages 337-361
  14. Human Health Risk Assessment of Perfluoroalkyl Acids

    • John L. Butenhoff, Joseph V. Rodricks
    Pages 363-418
  15. Conclusions and Recommendations

    • Jamie C. DeWitt
    Pages 479-482
  16. Back Matter

    Pages 483-495

About this book

This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight.

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health.

This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

Editors and Affiliations

  • Brody School of Medicine, East Carolina University, Greenville, USA

    Jamie C. DeWitt

Bibliographic Information

  • Book Title: Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

  • Editors: Jamie C. DeWitt

  • Series Title: Molecular and Integrative Toxicology

  • DOI: https://doi.org/10.1007/978-3-319-15518-0

  • Publisher: Humana Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-15517-3Published: 27 April 2015

  • Softcover ISBN: 978-3-319-37917-3Published: 06 October 2016

  • eBook ISBN: 978-3-319-15518-0Published: 14 April 2015

  • Series ISSN: 2168-4219

  • Series E-ISSN: 2168-4235

  • Edition Number: 1

  • Number of Pages: XIII, 495

  • Number of Illustrations: 34 b/w illustrations, 15 illustrations in colour

  • Topics: Pharmacology/Toxicology, Environmental Health, Ecotoxicology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access