Deterministic Kinetics in Chemistry and Systems Biology

1. Front Matter

   Pages i-x

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2. Rates and Rate Equations

   • Gábor Lente

   Pages 1-20

3. Solving Rate Equations

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   Pages 21-59

4. Inevitable Approximations

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   Pages 61-89

5. Information from Parameter Values

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   Pages 91-109

6. Common Pitfalls

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   Pages 111-129

7. Back Matter

   Pages 131-135

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This book gives a concise overview of the mathematical foundations of kinetics used in chemistry and systems biology. The analytical and numerical methods used to solve complex rate equations with the widely used deterministic approach will be described, with primary focus on practical aspects important in designing experimental studies and the evaluation of data. The introduction of personal computers transformed scientific attitudes in the last two decades considerably as computational power ceased to be a limiting factor. Despite this improvement, certain time-honored approximations in solving rate equations such as the pre-equilibrium or the steady-state approach are still valid and necessary as they concern the information content of measured kinetic traces. The book shows the role of these approximations in modern kinetics and will also describe some common misconceptions in this field.

• Activation Parameters
• Approximations for Rate Equations
• Competition Kinetics
• Complex Rate Equations
• Deterministic Approach
• Kinetics in Systems Biology
• Rate Determining Step
• Solving Kinetic Equations
• Solving Rate Equations
• Statistical Kinetics
• Steady-state Approximation
• Systems Biology

• Dept, of Inorganic and Analytical Chem., University of Debrecen, Debrecen, Hungary

  Gábor Lente

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