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Advances in Biochemistry in Health and Disease

Protein Kinase CK2 Cellular Function in Normal and Disease States

Editors: Ahmed, Khalil, Issinger, Olaf-Georg, Szyszka, Ryszard (Eds.)

  • CK2 is a potential target of drug development for improved cancer therapy
  • State-of-the-art information on the critical role of CK2 in cellular function and cancer biology​
  • Crucial tool for post-graduate students and investigators in the field of cancer biology
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Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-14544-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-14543-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 18, 2016
  • ISBN 978-3-319-37986-9
  • Free shipping for individuals worldwide
About this book

Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

About the authors

Dr. Khalil Ahmed is a Professor at the University of Minnesota, and a Senior Research Career Scientist at Minneapolis VA Health Care System, Minneapolis, Minnesota, U.S.A. He has a long history of studies on the functional biology of protein kinase CK2 in normal and neoplastic cells. He originally described the signal mediated dynamic shuttling of CK2 in the cell, and discovered the role of CK2 as a suppressor of apoptosis. His current research is focused on the mechanism of CK2 regulation of cell death. He is also studying the development of molecular therapeutic strategies using a nanomedicine approach for treatment of prostate and other cancers.

Dr. Olaf-Georg Issinger is a Professor at the University of Southern Denmark, Odense, Denmark. He has been involved in the initial cloning and characterization of protein kinase CK2, a prerequisite for the elucidation of its structure in the absence and presence of specific interaction molecules. His current research focuses on the exploration of cellular signaling pathways in cell lines with respect to the role of various protein kinases using newly characterized kinase inhibitors identified by screening small chemical compound libraries.

Dr. Ryszard Szyszka is a Professor at the John Paul II Catholic University of Lublin, Poland. He is head of the Department of Molecular Biology and Dean of the Faculty of Biotechnology and Environmental Sciences. His research is focused on the identification and characterization of new substrates of protein kinase CK2 from Saccharomyces cerevisiae. Further areas of interest include the structure and regulation of yeast CK2, and discovery of novel CK2 inhibitors. 

Table of contents (20 chapters)

  • Yeast Asf1 Protein as Modulator of Protein Kinase CK2 Activity

    Baier, Andrea (et al.)

    Pages 3-16

  • Impressions from the Conformational and Configurational Space Captured by Protein Kinase CK2

    Hochscherf, Jennifer (et al.)

    Pages 17-33

  • Structural Basis of CK2 Regulation by Autoinhibitory Oligomerization

    Lolli, Graziano (et al.)

    Pages 35-47

  • Maize RNA-Binding Protein ZmTGH: A New Partner for CK2β1 Regulatory Subunit

    Vélez-Bermúdez, Isabel Cristina (et al.)

    Pages 49-55

  • CK2 in Organ Development, Physiology, and Homeostasis

    Ortega, Charina E. (et al.)

    Pages 59-79

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-14544-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-14543-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 18, 2016
  • ISBN 978-3-319-37986-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Protein Kinase CK2 Cellular Function in Normal and Disease States
Editors
  • Khalil Ahmed
  • Olaf-Georg Issinger
  • Ryszard Szyszka
Series Title
Advances in Biochemistry in Health and Disease
Series Volume
12
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-14544-0
DOI
10.1007/978-3-319-14544-0
Hardcover ISBN
978-3-319-14543-3
Softcover ISBN
978-3-319-37986-9
Edition Number
1
Number of Pages
XXIII, 378
Number of Illustrations
31 b/w illustrations, 60 illustrations in colour
Topics