Advances in Experimental Medicine and Biology

Recent Advances in Prolactin Research

Editors: Diakonova, PhD, Maria (Ed.)

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  • Serves a large number of scientists and clinicians who are interested in the normal and patho physiology of prolactin
  • Gives an overview of major advances in the field of prolactin signaling pathways and regulation of prolactin gene expression
  • Discusses the role of PRL in adipocytes, immune response, angiogenesis, as well as in prostate tumorogenesis
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eBook $119.00
price for USA in USD
  • ISBN 978-3-319-12114-7
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $169.99
price for USA in USD
Softcover $159.99
price for USA in USD
About this book

Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions.

Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Prolactin (PRL) in Adipose Tissue: Regulation and Functions

    Pages 1-35

    Ben-Jonathan, Nira (et al.)

  • Signaling Pathways Regulating Pituitary Lactotrope Homeostasis and Tumorigenesis

    Pages 37-59

    Booth, Allyson K. (et al.)

  • The Many Faces of Prolactin in Breast Cancer

    Pages 61-81

    Chen, Wen Y, Ph.D.

  • Regulation of Blood Vessels by Prolactin and Vasoinhibins

    Pages 83-95

    Clapp, Dr. Carmen (et al.)

  • Tyrosyl Phosphorylated Serine-Threonine Kinase PAK1 is a Novel Regulator of Prolactin-Dependent Breast Cancer Cell Motility and Invasion

    Pages 97-137

    Hammer, Alan (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-319-12114-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $169.99
price for USA in USD
Softcover $159.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Recent Advances in Prolactin Research
Editors
  • Maria Diakonova, PhD
Series Title
Advances in Experimental Medicine and Biology
Series Volume
846
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-12114-7
DOI
10.1007/978-3-319-12114-7
Hardcover ISBN
978-3-319-12113-0
Softcover ISBN
978-3-319-35276-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 281
Number of Illustrations
9 b/w illustrations, 45 illustrations in colour
Topics