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Studies in Mechanobiology, Tissue Engineering and Biomaterials

The Mechanobiology of Obesity and Related Diseases

Editors: Gefen, Amit, Benayahu, Dafna (Eds.)

  • Describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies
  • Includes the important topics at the frontier of this field
  • Written by important scientists in the field
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eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-09336-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-09335-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 28, 2016
  • ISBN 978-3-319-37626-4
  • Free shipping for individuals worldwide
About this book

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.

There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

Table of contents (12 chapters)

  • Mechanical Behavior and Properties of Adipose Tissue

    Oomens, Cees (et al.)

    Pages 3-9

  • Mathematical Models of Adipose Tissue Dynamics

    Jo, Junghyo (et al.)

    Pages 11-34

  • Mechanical Stretching and Signaling Pathways in Adipogenesis

    Tanabe, Yoshiyuki (et al.)

    Pages 35-62

  • Role of Mechanical Stimulations in Directing Mesenchymal Stem Cell Adipogenesis

    Stoll, Hillary (et al.)

    Pages 63-87

  • The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

    Shoham, Naama (et al.)

    Pages 89-103

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-09336-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-09335-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: October 28, 2016
  • ISBN 978-3-319-37626-4
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
The Mechanobiology of Obesity and Related Diseases
Editors
  • Amit Gefen
  • Dafna Benayahu
Series Title
Studies in Mechanobiology, Tissue Engineering and Biomaterials
Series Volume
16
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-319-09336-9
DOI
10.1007/978-3-319-09336-9
Hardcover ISBN
978-3-319-09335-2
Softcover ISBN
978-3-319-37626-4
Series ISSN
1868-2006
Edition Number
1
Number of Pages
X, 296
Topics