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Advances in Experimental Medicine and Biology

Protein Conformational Dynamics

Editors: Han, Ke-li, Zhang, Xin, Yang, Ming-jun (Eds.)

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  • Covering both the description of widely used theoretical approaches and the applications of these methods in the study of protein dynamics
  • A thorough and extensive exploration and description of recent advances in the computational study of protein dynamics
  • Manifests the important role of the dynamic personalities of biological molecules in a variety of significant biological processes
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  • Due: October 14, 2016
  • ISBN 978-3-319-35389-0
  • Free shipping for individuals worldwide
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About this book

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression.

 

On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function.

 

On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Protein Folding Simulations by Generalized-Ensemble Algorithms

    Pages 1-27

    Yoda, Takao (et al.)

  • Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules

    Pages 29-66

    Da, Lin-Tai (et al.)

  • Understanding Protein Dynamics Using Conformational Ensembles

    Pages 67-85

    Salvatella, X.

  • Generative Models of Conformational Dynamics

    Pages 87-105

    Langmead, Christopher James, Ph.D.

  • Generalized Spring Tensor Models for Protein Fluctuation Dynamics and Conformation Changes

    Pages 107-135

    Na, Hyuntae (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-02970-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-02969-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: October 14, 2016
  • ISBN 978-3-319-35389-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
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Bibliographic Information

Bibliographic Information
Book Title
Protein Conformational Dynamics
Editors
  • Ke-li Han
  • Xin Zhang
  • Ming-jun Yang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
805
Copyright
2014
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-02970-2
DOI
10.1007/978-3-319-02970-2
Hardcover ISBN
978-3-319-02969-6
Softcover ISBN
978-3-319-35389-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 488
Number of Illustrations
21 b/w illustrations, 102 illustrations in colour
Topics

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