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Advances in Research on Neurodegeneration

3 & 4

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. Y. Mizuno

    1. Department of Neurology, Juntendo University, Tokyo, Japan

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  2. M. B. H. Youdim

    1. Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

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  3. D. B. Calne

    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

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  4. R. Horowski

    1. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

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  5. W. Poewe

    1. Department of Neurology, University of Innsbruck, Austria

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  6. P. Riederer

    1. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

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Part of the book series: Journal of Neural Transmission. Supplementa (NEURAL SUPPL, volume 49)

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Table of contents (26 papers)

  1. Front Matter

    Pages I-VIII
    Download chapter PDF

  2. Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques

    • B. J. Hoffer, L. Olson
    Pages 1-10

  3. Models of Alzheimer’s disease: cellular and molecular aspects

    • S. Hoyer
    Pages 11-21

  4. The relationship of Alzheimer-type pathology to dementia in Parkinson’s disease

    • K. Jendroska
    Pages 23-31

  5. Models to study the role of neurotrophic factors in neurodegeneration

    • D. Lindholm
    Pages 33-42

  6. Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, Sl00ß

    • K. Kojima, H. Wekerle, H. Lassmann, T. Berger, Ch. Linington
    Pages 43-51

  7. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis and their application for new therapeutic strategies

    • R. Martin
    Pages 53-67

  8. Nigrostriatal neuronal death in Parkinson’s disease — a passive or an active genetically-controlled process?

    • I. Ziv, A. Barzilai, D. Offen, N. Nardi, E. Melamed
    Pages 69-76

  9. Animal model and in vitro studies of anti neurofilament antibodies mediated neurodegeneration in Alzheimer’s disease

    • L. Oron, V. Dubovik, L. Novitsky, D. Eilam, D. M. Michaelson
    Pages 77-84

  10. Cop 1 as a candidate drug for multiple sclerosis

    • D. Teitelbaum, R. Arnon, M. Sela
    Pages 85-91

  11. Possible role of the cholinergic system and disease models

    • M. Weinstock
    Pages 93-102

  12. Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites

    • T. G. Hastings, M. J. Zigmond
    Pages 103-110

  13. Role of interferons in demyelinating disease

    • K. P. Johnson
    Pages 111-115

  14. Role of interferons in demyelinating diseases

    • B. G. W. Arnason, A. Toscas, A. Dayal, Z. Qu, A. Noronha
    Pages 117-123

  15. Mechanism of amyloid β protein induced neuronal cell death: current concepts and future perspectives

    • C. Behl, Y. Sagara
    Pages 125-134

  16. From prion diseases to Alzheimer’s disease

    • K. K. Hsiao
    Pages 135-144

  17. A phosphorylation cascade in the basal ganglia of the mammalian brain: regulation by the D-1 dopamine receptor A mathematical model of known biochemical reactions

    • J. W. Kebabian
    Pages 145-153

  18. Molecular heterogeneity of neurotransporters: implications for neurodegeneration

    • K. P. Lesch, U. Balling, M. Seemann, A. Teufel, D. Bengel, A. Heils et al.
    Pages 155-167

  19. Central nervous system cytokines and their relevance for neurotoxicity and apoptosis

    • J. Licinio
    Pages 169-175

  20. Genetics of multiple sclerosis — how could disease-associated HLA-types contribute to pathogenesis?

    • R. Martin
    Pages 177-194
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Keywords

About this book

Neurodegeneration is one of the most important subjects of the investigation now and in the coming 21st century. Alzheimer's disease is the leading cause of dementia in the elderly people and Parkinson's disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. Many others are suffering from intractable neurodegener­ ative disorders such as amyotrophic lateral sclerosis, Huntington's disease, or spinocerebellar degeneration. No truly effective treatment is available for any of these neurodegenerative disorders except for Parkinson's disease; even in Parkinson's disease, still it is impossible to slow down the disease process with the currently available treatment. It is urgently needed to develop new effective technique to halt or slow down the disease process in each of those disorders. Recent advance in the molecular biological and molecular genetic technique has brought us great progress in the understanding of etiology and pathogenesis of these disorders, but still it is not known how neurons are going to die in these disorders. To explore the question, mutual cooperation and exchange of ideas between basic scientists and clinical peoples are of utmost importance.

Editors and Affiliations

  • Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  • Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

  • Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  • Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  • Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  • Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

Bibliographic Information

  • Book Title: Advances in Research on Neurodegeneration

  • Book Subtitle: 3 & 4

  • Editors: Y. Mizuno, M. B. H. Youdim, D. B. Calne, R. Horowski, W. Poewe, P. Riederer

  • Series Title: Journal of Neural Transmission. Supplementa

  • DOI: https://doi.org/10.1007/978-3-7091-6844-8

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Wien 1997

  • Softcover ISBN: 978-3-211-82934-9Published: 22 July 1997

  • eBook ISBN: 978-3-7091-6844-8Published: 07 March 2013

  • Series ISSN: 0303-6995

  • Edition Number: 1

  • Number of Pages: VIII, 280

  • Topics: Neurology, Psychiatry, Pathology, Pharmacology/Toxicology, Neurosciences

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