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Advances in Research on Neurodegeneration

Volume 5

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. P. Riederer

    1. Department of Psychiatry, University of Würzburg, Germany

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  2. D. B. Calne

    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

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  3. R. Horowski

    1. Clinical Research, Schering AG, Berlin, Germany

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  4. Y. Mizuno

    1. Department of Neurology, Juntendo University, Tokyo, Japan

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  5. W. Poewe

    1. Department of Neurology, University of Innsbruck, Austria

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  6. M. B. H. Youdim

    1. Faculty of Medicine, Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

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Part of the book series: Journal of Neural Transmission. Supplementa (NEURAL SUPPL, volume 50)

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Table of contents (19 papers)

  1. Front Matter

    Pages I-VIII
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  2. Brain imaging revisited

    1. Front Matter

      Pages 1-1
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    2. Magnetic Resonance: A multimodal approach to the brain?

      • J. Laubenberger
      Pages 3-8

    3. Measurement of the dopaminergic degeneration in Parkinson’s disease with [123I]β-CIT and SPECT

      • T. Brücke, S. Asenbaum, W. Pirker, S. Djamshidian, S. Wenger, Ch. Wöber et al.
      Pages 9-24

    4. rCBF SPECT in Parkinson’s disease patients with mental dysfunction

      • S. Bissessur, G. Tissingh, E. Ch. Wolters, Ph. Scheltens
      Pages 25-30

    5. IBZM- and CIT-SPECT of the dopaminergic system in parkinsonism

      • G. Tissingh, J. Booij, A. Winogrodzka, E. A. van Royen, E. Ch. Wolters
      Pages 31-37

    6. Pathophysiology of movement disorders studied using PET

      • K. L. Leenders
      Pages 39-46

    7. Contributions of Positron Emission Tomography to elucidating the pathogenesis of Idiopathic Parkinsonism and Dopa Responsive Dystonia

      • D. B. Calne, R. de la Fuente-Fernández, A. Kishore
      Pages 47-52

  3. Endogenous and exogenous neurotoxins

    1. Front Matter

      Pages 53-53
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    2. Mechanism of 6-hydroxydopamine neurotoxicity

      • Yelena Glinka, M. Gassen, M. B. H. Youdim
      Pages 55-66

    3. Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons

      • A. Shirvan, I. Ziv, A. Barzilai, R. Djaldeti, R. Zilkh-Falb, T. Michlin et al.
      Pages 67-78

    4. Neuronal vulnerability in Parkinson’s disease

      • Etienne C. Hirsch, B. Faucheux, P. Damier, A. Mouatt-Prigent, Y. Agid
      Pages 79-88

    5. N-Methyl-(R)salsolinol as a dopaminergic neurotoxin: From an animal model to an early marker of Parkinson’s disease

      • M. Naoi, W. Maruyama, P. Dostert, Y. Hashizume
      Pages 89-105

    6. The halogenated tetrahydro-β-carboline “TaClo”: A progressively-acting neurotoxin

      • Christine Heim, K.-H. Sontag
      Pages 107-111

  4. Programmed cell death, apoptosis, necrosis and in between

    1. Front Matter

      Pages 113-113
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    2. Developmental and genetic regulation of programmed neuronal death

      • M. Weller, J. B. Schulz, U. Wüllner, P. A. Löschmann, T. Klockgether, J. Dichgans
      Pages 115-123

    3. Apoptosis in neurodegenerative disorders

      • H. Mochizuki, H. Mori, Y. Mizuno
      Pages 125-140

    4. Mechanisms of cell death in Alzheimer’s disease

      • C. Bancher, H. Lassmann, H. Breitschopf, K. A. Jellinger
      Pages 141-152

    5. Assessment of neurotoxicity and “neuroprotection”

      • Muriel O’Byrne, K. Tipton, G. McBean, H. Kollegger
      Pages 153-164

  5. Immunoinflammatory mechanisms, Infestive diseases causing neurological disorders

    1. Front Matter

      Pages 165-165
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Keywords

About this book

Volume 5 of the series "Advances in Research on Neurodegeneration" is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un­ derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo­ gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and chemical limitations of these techniques, even under optimal conditions, anatomical resolution can be improved to the extent that neuro­ degenerative diseases can be diagnosed earlier than currently possible and a confident diagnosis made. The possibilities of using neuroimaging techniques to provide information regarding the effects of neuroprotective or neuroregen­ erative therapeutic strategies, and for correlating the results of neuropsycho­ logical research with imaging data are also discussed. The second section is concerned with the significance of endogenous or exogenous neurotoxins as triggers for neurodegenerative processes that may lead to Parkinsonism. Vulnerability factors, which include such factors as nerve ending sensitivity, the synergistic effects of drugs and the various mechanisms underlying different toxins are discussed.

Editors and Affiliations

  • Department of Psychiatry, University of Würzburg, Germany

    P. Riederer

  • Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  • Clinical Research, Schering AG, Berlin, Germany

    R. Horowski

  • Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  • Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  • Faculty of Medicine, Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

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