Journal of Neural Transmission. Supplementa

Cell and Animal Models in Aging and Dementia Research

Editors: Hoyer, Siegfried, Müller, Dorothea, Plaschke, Konstanze (Eds.)

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About this book

Although age has been recognized as a risk factor for late-onset dementia of Alzheimer type, its etiology is unknown as yet. Several age-related metabolic abnormalities may thus become important for the pathogenesis of the late-onset form. Studies at the cellular/molecular level in brain tissue are possible post mortem, but lack information on the beginning of the disorder. In this supplement, different approaches are dealt with how to induce structural and/or metabolic abnormalities in relevant cell cultures, in brain slices and in experimental animals, and how behavioral changes parallel the metabolic variations.

Table of contents (20 chapters)

  • Primary cultures of neurons for testing neuroprotective drug effects

    Oberpichler-Schwenk, H. (et al.)

    Pages 1-20

  • Regulation of proteolytic processing of the amyloid β-protein precursor of Alzheimer’s disease in transfected cell lines and in brain slices

    Nitsch, Dr. R. M. (et al.)

    Pages 21-27

  • Glutamate, beta-amyloid precursor proteins, and calcium mediated neurofibrillary degeneration

    Smith-Swintosky, Dr. V. L. (et al.)

    Pages 29-45

  • An aggregate brain cell culture model for studying neuronal degeneration and regeneration

    Chatterjee, Dr. S. S. (et al.)

    Pages 47-60

  • The organotypic entorhinal-hippocampal complex slice culture of adolescent rats. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders

    Diekmann, Dr. S. (et al.)

    Pages 61-71

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-7091-9350-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-211-82549-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell and Animal Models in Aging and Dementia Research
Editors
  • Siegfried Hoyer
  • Dorothea Müller
  • Konstanze Plaschke
Series Title
Journal of Neural Transmission. Supplementa
Series Volume
44
Copyright
1994
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag / Wien
eBook ISBN
978-3-7091-9350-1
DOI
10.1007/978-3-7091-9350-1
Softcover ISBN
978-3-211-82549-5
Series ISSN
0303-6995
Edition Number
1
Number of Pages
VIII, 272
Number of Illustrations and Tables
63 b/w illustrations
Topics