Happy Holidays—Our $30 Gift Card just for you, and books ship free! Shop now>>

Journal of Neural Transmission. Supplementa

Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors

Editors: Marescaux, C., Vergnes, M., Bernasconi, R. (Eds.)

Free Preview

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-7091-9206-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-211-82340-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Human absence epilepsies

    Pages 1-6

    Loiseau, Dr. P.

  • Pharmacological models of generalized absence seizures in rodents

    Pages 7-19

    Snead, O. Carter, III, M.D.

  • The tottering mouse: a critical review of its usefulness in the study of the neuronal mechanisms underlying epilepsy

    Pages 21-36

    Kostopoulos, Dr. G. K.

  • Genetic absence epilepsy in rats from Strasbourg — A review

    Pages 37-69

    Marescaux, Dr. C. (et al.)

  • Cortical and thalamic lesions in rats with genetic absence epilepsy

    Pages 71-83

    Vergnes, Dr. M. (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-7091-9206-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-211-82340-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors
Editors
  • C. Marescaux
  • M. Vergnes
  • R. Bernasconi
Series Title
Journal of Neural Transmission. Supplementa
Series Volume
35
Copyright
1992
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-9206-1
DOI
10.1007/978-3-7091-9206-1
Softcover ISBN
978-3-211-82340-8
Series ISSN
0303-6995
Edition Number
1
Number of Pages
VII, 200
Topics