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Journal of Neural Transmission. Supplementa

Advances in Down Syndrome Research

Editors: Lubec, Gert (Ed.)

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  • ISBN 978-3-7091-6721-2
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Hardcover $199.99
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About this book

"Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • A new mouse model for Down syndrome

    Pages 1-20

    Kazuki, Y. (et al.)

  • Predicting pathway perturbations in Down syndrome

    Pages 21-37

    Gardiner, Dr. K.

  • Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer’s disease

    Pages 39-49

    Shim, K. S. (et al.)

  • Cell cycle and cell size regulation in Down Syndrome cells

    Pages 51-58

    Rosner, M. (et al.)

  • Transcription factor REST dependent proteins are comparable between Down Syndrome and control brains: challenging a hypothesis

    Pages 59-66

    Sohn, S. Y. (et al.)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-7091-6721-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-211-40781-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-211-40776-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Down Syndrome Research
Editors
  • Gert Lubec
Series Title
Journal of Neural Transmission. Supplementa
Series Volume
67
Copyright
2003
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag/Wien
eBook ISBN
978-3-7091-6721-2
DOI
10.1007/978-3-7091-6721-2
Hardcover ISBN
978-3-211-40781-3
Softcover ISBN
978-3-211-40776-9
Series ISSN
0303-6995
Edition Number
1
Number of Pages
X, 242
Number of Illustrations
29 b/w illustrations
Topics