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Milestones in Drug Therapy

Methotrexate

Editors: Cronstein, Bruce N., Bertino, Joseph R. (Eds.)

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  • ISBN 978-3-0348-8452-5
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About this book

Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate's development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag­ onism was soon applied to the development of antibacterial and anti­ parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat­ ment of a variety of infections.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Methotrexate: historical aspects

    Pages 1-7

    Bertino, Joseph R.

  • Methotrexate, its mechanism of action in malignant disease and mechanisms of resistance by malignant cells

    Pages 9-29

    Gorlick, Richard

  • Current use of methotrexate in the treatment of malignancies in adults

    Pages 31-48

    O’Leary, James (et al.)

  • The use of methotrexate in the treatment of childhood malignancies

    Pages 49-63

    Kamen, Barton A. (et al.)

  • The mechanisms of methotrexate’s action in the treatment of inflammatory disease

    Pages 65-82

    Cronstein, Bruce N. (et al.)

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-3-0348-8452-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-3-0348-9573-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Methotrexate
Editors
  • Bruce N. Cronstein
  • Joseph R. Bertino
Series Title
Milestones in Drug Therapy
Copyright
2000
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8452-5
DOI
10.1007/978-3-0348-8452-5
Softcover ISBN
978-3-0348-9573-6
Series ISSN
2296-6056
Edition Number
1
Number of Pages
IX, 139
Topics