Progress in Inflammation Research

Novel Cytokine Inhibitors

Editors: Higgs, Gerry, Henderson, Brian (Eds.)

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About this book

Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Targets for modulating cytokine responses in inflammatory and infectious diseases

    Pages 1-8

    Henderson, Brian (et al.)

  • Cell signaling and cytokine induction by lipopolysaccharide

    Pages 9-42

    MacKichan, Mary Lee (et al.)

  • Regulation of cytokine production by inhibitors of cell signalling

    Pages 43-82

    Allen, Rodger A. (et al.)

  • Oligonucleotide-based drugs in the control of cytokine synthesis

    Pages 83-101

    Crooke, Stanley T.

  • Inhibiting cytokine-processing enzymes

    Pages 103-122

    Croucher, Peter I. (et al.)

Buy this book

eBook $74.99
price for USA in USD
  • ISBN 978-3-0348-8450-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA in USD
  • ISBN 978-3-0348-9572-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Novel Cytokine Inhibitors
Editors
  • Gerry Higgs
  • Brian Henderson
Series Title
Progress in Inflammation Research
Copyright
2000
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8450-1
DOI
10.1007/978-3-0348-8450-1
Softcover ISBN
978-3-0348-9572-9
Series ISSN
0379-0363
Edition Number
1
Number of Pages
VIII, 270
Topics