Progress in Inflammation Research

Muscarinic Receptors in Airways Diseases

Editors: Zaagsma, Johan, Meurs, Herman, Roffel, Ad F. (Eds.)

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About this book

What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Cholinergic and noncholinergic parasympathetic control of airway smooth muscle

    Pages 1-24

    Undem, Bradley J. (et al.)

  • Role of non-neuronal and neuronal acetylcholine in the airways

    Pages 25-62

    Wessler, Ignaz K. (et al.)

  • Identification, localization and function of muscarinic receptor subtypes in the airways

    Pages 63-85

    Roffel, Ad F. (et al.)

  • Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle

    Pages 87-106

    Eglen, Richard M. (et al.)

  • Dysfunction of prejunctional muscarinic M2 receptors: role of environmental factors

    Pages 107-120

    Adamko, Darryl J. (et al.)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-0348-8358-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.99
price for USA in USD
  • ISBN 978-3-0348-9532-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Muscarinic Receptors in Airways Diseases
Editors
  • Johan Zaagsma
  • Herman Meurs
  • Ad F. Roffel
Series Title
Progress in Inflammation Research
Copyright
2001
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8358-0
DOI
10.1007/978-3-0348-8358-0
Softcover ISBN
978-3-0348-9532-3
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XI, 266
Topics