Skip to main content
SpringerLink
Log in
Birkhäuser

Free Radicals and Aging

  • Book
  • © 1992

Overview

Editors:
  1. Ingrid Emerit

    1. C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, Paris, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Britton Chance

    1. Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experientia Supplementum (EXS, volume 62)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (42 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Intrinsic Aging Process

    1. Theoretical Considerations

      1. Free radical theory of aging: History
        • Denham Harman
        Pages 1-10
      2. Free radical theory of aging: View against the reliability theory
        • Vitali K. Koltover
        Pages 11-19
      3. The rate of DNA damage and aging
        • Michael G. Simic
        Pages 20-30
      4. Genetic stability and oxidative stress: Common mechanisms in aging and cancer
        • Richard G. Cutler
        Pages 31-46
      5. Oxygen-induced mitochondrial damage and aging
        • Jaime Miquel, Emilio de Juan, Inmaculada Sevila
        Pages 47-57

    2. Biochemical Markers of Aging

      1. Instabilities of metabolic regulations in aging
        • Britton Chance, William W. Bank, Cheng-dou Zhang
        Pages 58-63
      2. Protein modification in aging
        • E. R. Stadtman, P. E. Starke-Reed, C. N. Oliver, J. M. Carney, R. A. Floyd
        Pages 64-72
      3. Mitochondrial production of oxygen free radicals in the heart muscle during the life span of the rat: Peak at middle age
        • Carlo Guarnieri, Claudio Muscari, Claudio M. Caldarera
        Pages 73-77
      4. Lipofuscinogenesis in a model system of cultured cardiac myocytes
        • Massoud R. Marzabadi, Dazhong Yin, Ulf T. Brunk
        Pages 78-88
      5. Cellular clones and transgenic mice overexpressing copper — zinc superoxide dismutase: Models for the study of free radical metabolism and aging
        • Irène Ceballos-Picot, Annie Nicole, Pierre-Marie Sinet
        Pages 89-98
      6. The importance of antioxidant enzymes in cellular aging and degeneration
        • José Remacle, Carine Michiels, Martine Raes
        Pages 99-108
      7. Relationship between antioxidants, lipid peroxidation and aging
        • G. Barja de Quiroga, M. López-Torres, R. Pérez-Campo
        Pages 109-123
      8. The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells
        • Werner G. Siems, Tilman Grune, Beatrix Beierl, Helmward Zollner, Hermann Esterbauer
        Pages 124-135
      9. Effect of aging on glutathione metabolism. Protection by antioxidants
        • J. Viña, J. Sastre, V. Anton, L. Bruseghini, A. Esteras, M. Asensi
        Pages 136-144

  3. Age-Related Diseases

    1. Cardiovascular System

      1. Inhibition of LDL oxidation by antioxidants
        • Hermann Esterbauer, Georg Waeg, Herbert Puhl, M. Dieber-Rotheneder, Franz Tatzber
        Pages 145-157
      2. Desialylated low density lipoproteins and atherosclerosis
        • Nicole Dousset, Jean Claude Dousset, Marie Laure Soléra, Pierre Valdiguié
        Pages 158-163
      3. Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro
        • Daniel Boscoboinik, Eric Chatelain, Gianna-M. Bartoli, Angelo Azzi
        Pages 164-177

    2. Brain

      1. Oxidative damage in Alzheimer’s dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions
        • Peter H. Evans, Eiji Yano, Jacek Klinowski, Ernst Peterhans
        Pages 178-189
      2. The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome
        • Karen L. Brugge, Sharon Nichols, Dean Delis, Tsunao Saitoh, Doris Truaner
        Pages 190-198
Back to top

Keywords

About this book

Among the various theories proposed to account for the process of aging, the free radical theory is of practical interest since it includes the possibility of retarding this process by administrating natural or synthetic antioxidants and free radical scavengers. The book "Free Radicals and Aging" summarizes knowledge accumulated during recent years in 42 reviews written by experts in the field. Aspects of free radical involvement in the intrinsic aging process and in age-related diseases, as well as the importance of the pro-antioxidant balance throughout life are discussed. Epidemiological studies from several European countries are reported showing correlations between low plasma levels of essential antioxidants and the occurence of coronary heart disease, cancer and cataract formation. Appropriate nutrition as well as prophylactic and therapeutic use of antioxidants are considered. This book represents a milestone in the field of age-related free radical biology and medicine. With contributions by: A. Azzi, B. Chance, R.G. Cutler, H. Esterbauer, P.H. Evans, F. Gey, C. Guarneri, D. Harman, N.I. Krinsky, M. Meydani, J. Miquel, A. Mori, L. Packer, C. Rice-Evans, M. Simic, A. Taylor, T. Yoshikawa.

Editors and Affiliations

  • C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, Paris, France

    Ingrid Emerit

  • Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA

    Britton Chance

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation