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Molecular and Cell Biology Updates

Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

Authors: ONG, PACKER

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About this book

Antioxidants inhibit the formation and spread of free radicals which can be damaging in biological systems. Free radicals form in biological systems through metabolism, but it is also realized that exogenous environmental sources, such as radiation, food, and drugs, contribute significantly to the generation of free radicals in biological systems. Being reactive species, free radicals are short-lived and do not travel far from cellular targets. Their concentration in biological systems is very low and is difficult to detect directly by electron spin resonance spectroscopy (ESR). Indirect methods of reactions of radicals with specific biomolecules are also sufficiently sensitive to detect quantitatively their presence. Thus the response of antioxidant defenses which react with radical species, can serve as an indirect measure that free radicals have been formed. Redox-based antioxidants change their oxidation state and antioxidants become free radicals themselves. Often, however, the antioxidants give rise to more persistent free radicals, sometimes owing to delocalization of the lone electron around ring structures (in vitamin E, ubiquinones, and certain carotenes). Persistent free radicals react only rarely and the precursors often can be regenerated in biological systems. In recent years, it is becoming clearer from biochemical studies on how the major lipophilic antioxidants work. Particular attention has been given to vitamin E and quinones found in animal and plant membranes and in carotenoids, for the protection of membranes in lipoprotein systems. Flavonoids form another rich and varied source of natural antioxidants.

Table of contents (49 chapters)

Table of contents (49 chapters)
  • New Horizons in Vitamin E Research — The Vitamin E Cycle, Biochemistry, and Clinical Applications

    Pages 1-16

    Packer, L.

  • The Reactivity of Tocotrienols and Other Lipid-Soluble Antioxidants Towards Peroxyl Radicals

    Pages 17-26

    Suarna, Cacang (et al.)

  • Physical/Chemical Studies of Vitamin E in Membranes

    Pages 27-46

    Govil, Girjesh (et al.)

  • Synergistic Effect of Lipid Hydroperoxyl Radical Scavenging and Lipid Hydroperoxide Reduction in the Inhibition of Lipid Peroxidation in Biomembranes

    Pages 47-51

    Maiorino, Matilde (et al.)

  • Determination of Rate Constants for Antioxidant Activity and use of the Crocin Assay

    Pages 52-64

    Bors, Wolf (et al.)

Buy this book

eBook $74.99
price for USA in USD
  • ISBN 978-3-0348-7432-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA in USD
  • ISBN 978-3-0348-7434-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications
Authors
Series Title
Molecular and Cell Biology Updates
Copyright
1992
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-7432-8
DOI
10.1007/978-3-0348-7432-8
Softcover ISBN
978-3-0348-7434-2
Edition Number
1
Number of Pages
XII, 642
Number of Illustrations
39 b/w illustrations
Topics

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