Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
Editors: Igaz, Peter (Ed.)
Free Preview- Discusses the diagnostic potential of circulating MicroRNAs
- Presents hypotheses on the potential biological relevance of circulating microRNAs
- Highlights the role of circulating microRNAs in epigenetics, tumor surveillance and interindvidual communication
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- About this book
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MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
- About the authors
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Peter Igaz has degrees in medicine and molecular biology. He works as an associate professor in medicine at Semmelweis University Budapest. He is very actively involved in research focusing on the genomics and bioinformatics of endocrine tumors; the study of microRNAs forms a special focus of his research. His research group was among the first to describe tissue microRNA profiles and microRNA biomarkers of malignancy in adrenocortical and adrenomedullary tumors, and circulating microRNAs in adrenocortical tumor patients. His group developed a novel microRNA target prediction algorithm and analyzed pathways involved in adrenal tumors with bioinformatics tools.
- Table of contents (14 chapters)
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Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy—The Concept of Circulating microRNAs
Pages 3-30
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Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers
Pages 31-53
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Technical Aspects Related to the Analysis of Circulating microRNAs
Pages 55-71
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Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors
Pages 75-122
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Circulating microRNA as Biomarkers in Hematological Malignancies
Pages 123-138
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Table of contents (14 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
- Editors
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- Peter Igaz
- Series Title
- Experientia Supplementum
- Series Volume
- 106
- Copyright
- 2015
- Publisher
- Springer Basel
- Copyright Holder
- Springer International Publishing Switzerland
- eBook ISBN
- 978-3-0348-0955-9
- DOI
- 10.1007/978-3-0348-0955-9
- Hardcover ISBN
- 978-3-0348-0953-5
- Series ISSN
- 1664-431X
- Edition Number
- 1
- Number of Pages
- XII, 288
- Number of Illustrations
- 3 b/w illustrations, 15 illustrations in colour
- Topics
