Galanin

1. Front Matter

   Pages i-x

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2. Galanin: A Multitalented Neuropeptide

   • T. Hökfelt, K. Tatemoto

   Pages 1-5

3. Galanin, Galanin Receptors, and Drug Targets

   • K. Mitsukawa, X. Lu, T. Bartfai

   Pages 7-23

4. Galanin Acts as a Trophic Factor to the Central and Peripheral Nervous Systems

   • S-A. Hobson, A. Bacon, C. R. Elliot-Hunt, F. E. Holmes, N. C. H. Kerr, R. Pope et al.

   Pages 25-38

5. Galanin and Spinal Pain Mechanisms: Past, Present, and Future

   • Xiao-Jun Xu, Tomas Hökfelt, Zsuzsanna Wiesenfeld-Hallin

   Pages 39-50

6. Galanin Family of Peptides in Skin Function

   • J. W. Bauer, R. Lang, M. Jakab, B. Kofler

   Pages 51-59

7. Galanin in Glia: Expression and Potential Roles in the CNS

   • Helmut Butzkueven, Andrew L. Gundlach

   Pages 61-69

8. Galanin and the Neuroendocrine Axes

   • Istvan Merchenthaler

   Pages 71-85

9. Galanin and Consummatory Behavior: Special Relationship with Dietary Fat, Alcohol and Circulating Lipids

   • Jessica R. Barson, Irene Morganstern, Sarah F. Leibowitz

   Pages 87-111

10. Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galanin

    • Zaida Díaz-Cabiale, Concepción Parrado, Manuel Narváez, Carmelo Millón, Araceli Puigcerver, Kjell Fuxe et al.

    Pages 113-131

11. Galanin Impairs Cognitive Abilities in Rodents: Relevance to Alzheimer’s Disease

    • J. N. Crawley

    Pages 133-141

12. Neuroprotective Role for Galanin in Alzheimer’s Disease

    • Scott E. Counts, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson

    Pages 143-162

13. Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour

    • Eugenia Kuteeva, Tomas Hökfelt, Tara Wardi, Sven Ove Ögren

    Pages 163-181

14. Galanin and Epilepsy

    • J. T. Lerner, R. Sankar, A. M. Mazarati

    Pages 183-194

15. Galanin and Addiction

    • Marina R. Picciotto

    Pages 195-208

16. Galanin Systems and Ischemia: Peptide and Receptor Plasticity in Neurons and Oligodendroglial Precursors

    • Pei-Juan Shen, Andrew L. Gundlach

    Pages 209-221

17. The Galanin System in Cancer

    • I. Rauch, Barbara Kofler

    Pages 223-241

18. Galanin Systems in Non-mammalian Vertebrates with Special Focus on Fishes

    • Elsie Tachie Mensah, Helene Volkoff, Suraj Unniappan

    Pages 243-262

19. Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproduction

    • Catherine B. Lawrence, Gregory S. Fraley

    Pages 263-280

20. Back Matter

    Pages 281-285

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Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

• Alzheimer's disease
• CNS
• alcohol
• behavior
• biological
• energy
• homeostasis
• molecule
• nervous system
• pain
• plasticity
• receptor
• receptors
• skin
• system

• Dept. Neuroscience, Karolinska Institute, Stockholm, Sweden

  Tomas Hökfelt

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