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Endothelial Dysfunction and Inflammation

  • Book
  • © 2010

Overview

Editors:
  1. Shauna Dauphinee

    1. BC Cancer Research Center, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Aly Karsan

    1. BC Cancer Research Centre, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • International authorship
  • Written by expert researchers
  • A useful reference for academic and industrial researchers, clinicians and trainees in the medical profession
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xii
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  2. Endothelial activation and dysfunction in sepsis

    • John M. Harlan
    Pages 1-13

  3. Heterogeneity in responses of microvascular endothelial cells during inflammation

    • Grietje Molema
    Pages 15-35

  4. Oxidative stress and endothelial dysfunction

    • Stephanie T. de Dios, Christopher G. Sobey, Grant R. Drummond
    Pages 37-64

  5. Post-translational regulation of eNOS activity in inflammation

    • Fanny Desjardins, Jean-Philippe Gratton
    Pages 65-80

  6. Endothelial dysfunction in pulmonary hypertension

    • Dominique Yelle, Lakshmi Kugathasan, Robin E. MacLaren, Duncan J. Stewart
    Pages 81-102

  7. Endothelial dysfunction in systemic hypertension

    • Carol Yu, Arpeeta Sharma, Andy Trane, Pascal Bernatchez
    Pages 103-117

  8. Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation

    • Bodo Levkau
    Pages 119-135

  9. Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature

    • Wang Min, Ting Wan, Yan Luo
    Pages 137-159

  10. AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes

    • Anna M. D. Watson, Aino Soro-Paavonen, Karin A. Jandeleit-Dahm
    Pages 161-174

  11. Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells

    • Jenny Jongstra-Bilen, Myron I. Cybulsky
    Pages 175-188

  12. Inflammation and endothelial dysfunction with aging

    • Mary K. Y. Lee, Paul M. Vanhoutte
    Pages 189-200

  13. Clinical approaches to assess endothelial function in vivo

    • Elizabeth A. Ellins, Julian P. Halcox
    Pages 201-217

  14. Therapeutic approaches towards targeting endothelial dysfunction

    • John H. Boyd, Keith R. Walley
    Pages 219-230

  15. Back Matter

    Pages 231-236
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Keywords

About this book

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Editors and Affiliations

  • BC Cancer Research Center, Vancouver, Canada

    Shauna Dauphinee

  • BC Cancer Research Centre, Vancouver, Canada

    Aly Karsan

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