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Nuclear Receptors

The Art and Science of Modulator Design and Discovery

Editors: Badr, Mostafa Z. (Ed.)

  • Covers how produced modulators are evaluated experimentally and eventually in relevant disease states, before reaching the phase of developing more efficient and/or less toxic therapies
  • Explains how scientists approach the task of designing modulators before the experimental phase
  • Presents a unique perspective through deciphering the thought process scientists go through in various phases of their work
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eBook $229.00
price for USA in USD
  • The eBook version of this title will be available soon
  • Due: November 30, 2021
  • ISBN 978-3-030-78315-0
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $299.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 2, 2021
  • ISBN 978-3-030-78314-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
About this book

Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases.

This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.


About the authors

Dr. Mostafa Z. Badr is a Professor Emeritus at the University of Missouri-Kansas City, USA. Dr. Badr obtained his Bachelor degree in Pharmacy and a Master’s degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University, Egypt. Dr. Badr subsequently obtained a Ph.D. Degree in Pharmacology and Toxicology from the University of Louisville, after which he received postdoctoral training in Toxicology at the University of North Carolina-Chapel Hill. In 1987 Dr. Badr accepted the position of Assistant Professor at the University of Missouri-Kansas City School of Pharmacy, where he retired as Professor in 2015.

 

Dr. Badr has authored and co-authored over 70 publications in peer-reviewed journals, and has published three previous books with Springer Nature. Dr. Badr founded the journal of PPAR Research and served as its Editor-in-Chief from 2005-2011, and the journal of Nuclear Receptor Research and served as its Editor-in-Chief from 2013 until 2019.

 

Mostafa Badr, Ph.D.

Kansas City, MO, USA

November 2020.

Buy this book

eBook $229.00
price for USA in USD
  • The eBook version of this title will be available soon
  • Due: November 30, 2021
  • ISBN 978-3-030-78315-0
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $299.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 2, 2021
  • ISBN 978-3-030-78314-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
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Bibliographic Information

Bibliographic Information
Book Title
Nuclear Receptors
Book Subtitle
The Art and Science of Modulator Design and Discovery
Editors
  • Mostafa Z. Badr
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG
eBook ISBN
978-3-030-78315-0
DOI
10.1007/978-3-030-78315-0
Hardcover ISBN
978-3-030-78314-3
Edition Number
1
Number of Pages
XI, 683
Number of Illustrations
82 b/w illustrations, 127 illustrations in colour
Topics