Overview
Covers how produced modulators are evaluated experimentally and eventually in relevant disease states, before reaching the phase of developing more efficient and/or less toxic therapies
Explains how scientists approach the task of designing modulators before the experimental phase
Presents a unique perspective through deciphering the thought process scientists go through in various phases of their work
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (23 chapters)
-
Front Matter
Keywords
About this book
This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Editors and Affiliations
About the editor
Dr. Mostafa Z. Badr is a Professor Emeritus at the University of Missouri-Kansas City, USA. Dr. Badr obtained his Bachelor degree in Pharmacy and a Master’s degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University, Egypt. Dr. Badr subsequently obtained a Ph.D. Degree in Pharmacology and Toxicology from the University of Louisville, after which he received postdoctoral training in Toxicology at the University of North Carolina-Chapel Hill. In 1987 Dr. Badr accepted the position of Assistant Professor at the University of Missouri-Kansas City School of Pharmacy, where he retired as Professor in 2015.
Dr. Badr has authored and co-authored over 70 publications in peer-reviewed journals, and has published three previous books with Springer Nature. Dr. Badr founded the journal of PPAR Research and served as its Editor-in-Chief from 2005-2011, and the journal of Nuclear Receptor Research and served as its Editor-in-Chief from 2013 until 2019.
Mostafa Badr, Ph.D.
Kansas City, MO, USA
November 2020.
Bibliographic Information
Book Title: Nuclear Receptors
Book Subtitle: The Art and Science of Modulator Design and Discovery
Editors: Mostafa Z. Badr
DOI: https://doi.org/10.1007/978-3-030-78315-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-78314-3Published: 28 September 2021
Softcover ISBN: 978-3-030-78438-6Published: 29 September 2022
eBook ISBN: 978-3-030-78315-0Published: 28 September 2021
Edition Number: 1
Number of Pages: XI, 679
Number of Illustrations: 82 b/w illustrations, 127 illustrations in colour
Topics: Cancer Research, Medical Biochemistry