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Tumor Suppressor Par-4

Structural Features, Molecular Mechanisms and Function

Editors: Rangnekar, Vivek M. (Ed.)

  • Highlights the structural features and molecular mechanisms of Par-4 function by global researchers
  • Provides researchers and clinicians with new insights into potential drug discovery and development for cancer and other human diseases
  • Describes future directions for research studies and novel, translational facets of the tumor suppressor protein
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eBook $169.00
price for USA in USD
  • The eBook version of this title will be available soon
  • Due: August 29, 2021
  • ISBN 978-3-030-73572-2
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $219.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: August 1, 2021
  • ISBN 978-3-030-73571-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
About this book

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.  Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

About the authors

​Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally discovered and identified the tumor suppressor protein Par-4/PAWR in 1993. 

Buy this book

eBook $169.00
price for USA in USD
  • The eBook version of this title will be available soon
  • Due: August 29, 2021
  • ISBN 978-3-030-73572-2
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $219.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: August 1, 2021
  • ISBN 978-3-030-73571-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Suppressor Par-4
Book Subtitle
Structural Features, Molecular Mechanisms and Function
Editors
  • Vivek M. Rangnekar
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-73572-2
DOI
10.1007/978-3-030-73572-2
Hardcover ISBN
978-3-030-73571-5
Edition Number
1
Number of Pages
VIII, 327
Number of Illustrations
3 b/w illustrations, 81 illustrations in colour
Topics