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Advances in Biochemical Engineering/Biotechnology

Digital Twins

Tools and Concepts for Smart Biomanufacturing

Editors: Herwig, Christoph, Pörtner, Ralf, Möller, Johannes (Eds.)

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  • First book to provide an overview of the role of digital twins in bioprocessing
  • Describes fundamental concepts and tools
  • Explores new and efficient methods for research and development, and smart manufacturing
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eBook $269.00
price for USA in USD
  • ISBN 978-3-030-71660-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-030-71659-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

This is the first of two volumes that together provide an overview of the latest advances in the generation and application of digital twins in bioprocess design and optimization.

Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing.

In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them.

This book explains the mathematical structure of digital twins, their development and the model’s respective parts, as well as concepts for the knowledge-driven generation and structural variability of digital twins. 

Covering fundamentals as well as applications, the two volumes offer the ideal introduction to the topic for researchers in academy and industry alike.

 

About the authors

Christoph Herwig is a Full Professor of Biochemical Engineering at the Vienna University of Technology (Austria), with a background in Bioprocess Engineering from the RWTH Aachen (Germany) and Ph.D. in Bioprocess Identification at the EPFL (Switzerland). Prior to his Ph.D. graduation, he has also worked in industry in the design and commissioning of large chemical facilities. His main research focuses on the development of data science methods for integrated and efficient bioprocess development along PAT and QbD principles for biopharmaceuticals. In 2013 he founded the company Exputec addressing data science solutions for the biopharma life cycle, which was fused in Körber AG in 2020.

 

Ralf Pörtner studied Chemical Engineering at the University of Dortmund (Germany), and received his Ph.D. at the Department of Mechanical Process Engineering of the same university. After a post-doctoral study at the University of Tsukuba (Japan), he took on the role of Senior Engineer and Head of the working group "Cell Culture and Tissue Engineering" at the Technical University of Hamburg (Germany). Since 2010 he is Honorary Professor at TH Mittelhessen University of Applied Sciences, Giessen (Germany). He is currently one of the coordinators of the research focus "Regeneration, Implants and Medical Technology" of the Technical University of Hamburg (Germany), and member of the directorate of the Research Center Medical Technology (FMTHH). His main research activities include the development of bioreactors, in particular for cell cultures and microbial reactions, as well as model-based control concepts, and tissue engineering.

 

Johannes Möller studied Bioprocess Engineering at the Hamburg University of Technology (TUHH), Germany, where he did his Ph.D. and worked as a scientist at the Institute of Bioprocess and Biosystems Engineering (Head: Prof. An-Ping Zeng). His research focuses on accelerated and knowledge-driven bioprocess design and optimization using novel statistical and computational methods. The main areas of interest are: Biosystems Engineering, software development for model-assisted bioprocess development and experimental design, and computational methods for bioprocess characterization and control. Since 2020, he joined a pharmaceutical company where he is responsible for the manufacturing of biopharmaceuticals, and he has also worked as an external scientist at TUHH.


Table of contents (7 chapters)

Table of contents (7 chapters)
  • Towards the Development of Digital Twins for the Bio-manufacturing Industry

    Pages 1-34

    Gargalo, Carina L. (et al.)

  • When Is an In Silico Representation a Digital Twin? A Biopharmaceutical Industry Approach to the Digital Twin Concept

    Pages 35-55

    Portela, Rui M. C. (et al.)

  • Digitalization and Bioprocessing: Promises and Challenges

    Pages 57-69

    Scheper, Thomas (et al.)

  • Usage of Digital Twins Along a Typical Process Development Cycle

    Pages 71-96

    Sinner, Peter (et al.)

  • Digital Seed Train Twins and Statistical Methods

    Pages 97-131

    Hernández Rodríguez, Tanja (et al.)

Buy this book

eBook $269.00
price for USA in USD
  • ISBN 978-3-030-71660-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-030-71659-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Digital Twins
Book Subtitle
Tools and Concepts for Smart Biomanufacturing
Editors
  • Christoph Herwig
  • Ralf Pörtner
  • Johannes Möller
Series Title
Advances in Biochemical Engineering/Biotechnology
Series Volume
176
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-71660-8
DOI
10.1007/978-3-030-71660-8
Hardcover ISBN
978-3-030-71659-2
Series ISSN
0724-6145
Edition Number
1
Number of Pages
VII, 262
Number of Illustrations
30 b/w illustrations, 52 illustrations in colour
Topics