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Advances in Biochemical Engineering/Biotechnology

Digital Twins

Applications to the Design and Optimization of Bioprocesses

Editors: Herwig, Christoph, Pörtner, Ralf, Möller, Johannes (Eds.)

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  • First book to provide an overview of the role of digital twins in bioprocessing
  • Shows the application of digital twins in various contexts
  • Explores new and efficient methods for research and development, and smart manufacturing
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eBook $269.00
price for USA in USD
  • ISBN 978-3-030-71656-1
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-030-71655-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

This is the second of two volumes that together provide an overview of the latest advances in the generation and application of digital twins in bioprocess design and optimization.

Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing.

In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them.

This book focuses on the application of digital twins in various contexts, e.g. computer-aided experimental design, seed train prediction, and lifeline analysis. Covering fundamentals as well as applications, the two volumes offers the ideal introduction to the topic for researchers in academy and industry alike.

About the authors

Christoph Herwig is a Full Professor of Biochemical Engineering at the Vienna University of Technology (Austria), with a background in Bioprocess Engineering from the RWTH Aachen (Germany) and Ph.D. in Bioprocess Identification at the EPFL (Switzerland). Prior to his Ph.D. graduation, he has also worked in industry in the design and commissioning of large chemical facilities. His main research focuses on the development of data science methods for integrated and efficient bioprocess development along PAT and QbD principles for biopharmaceuticals. In 2013 he founded the company Exputec addressing data science solutions for the biopharma life cycle, which was fused in Körber AG in 2020.

 

Ralf Pörtner studied Chemical Engineering at the University of Dortmund (Germany), and received his Ph.D. at the Department of Mechanical Process Engineering of the same university. After a post-doctoral study at the University of Tsukuba (Japan), he took on the role of Senior Engineer and Head of the working group "Cell Culture and Tissue Engineering" at the Technical University of Hamburg (Germany). Since 2010 he is Honorary Professor at TH Mittelhessen University of Applied Sciences, Giessen (Germany). He is currently one of the coordinators of the research focus "Regeneration, Implants and Medical Technology" of the Technical University of Hamburg (Germany), and member of the directorate of the Research Center Medical Technology (FMTHH). His main research activities include the development of bioreactors, in particular for cell cultures and microbial reactions, as well as model-based control concepts, and tissue engineering.

 

Johannes Möller studied Bioprocess Engineering at the Hamburg University of Technology (TUHH), Germany, where he did his Ph.D. and worked as a scientist at the Institute of Bioprocess and Biosystems Engineering (Head: Prof. An-Ping Zeng). His research focuses on accelerated and knowledge-driven bioprocess design and optimization using novel statistical and computational methods. The main areas of interest are: Biosystems Engineering, software development for model-assisted bioprocess development and experimental design, and computational methods for bioprocess characterization and control. Since 2020, he joined a pharmaceutical company where he is responsible for the manufacturing of biopharmaceuticals, and he has also worked as an external scientist at TUHH.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Potential of Integrating Model-Based Design of Experiments Approaches and Process Analytical Technologies for Bioprocess Scale-Down

    Pages 1-28

    Neubauer, Peter (et al.)

  • Digital Twins and Their Role in Model-Assisted Design of Experiments

    Pages 29-61

    Kuchemüller, Kim B. (et al.)

  • Digital Twins for Bioprocess Control Strategy Development and Realisation

    Pages 63-94

    Appl, Christian (et al.)

  • The Kalman Filter for the Supervision of Cultivation Processes

    Pages 95-125

    Yousefi-Darani, Abdolrahim (et al.)

  • The Challenge of Implementing Digital Twins in Operating Value Chains

    Pages 127-166

    Werner, Roman (et al.)

Buy this book

eBook $269.00
price for USA in USD
  • ISBN 978-3-030-71656-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-030-71655-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Digital Twins
Book Subtitle
Applications to the Design and Optimization of Bioprocesses
Editors
  • Christoph Herwig
  • Ralf Pörtner
  • Johannes Möller
Series Title
Advances in Biochemical Engineering/Biotechnology
Series Volume
177
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-71656-1
DOI
10.1007/978-3-030-71656-1
Hardcover ISBN
978-3-030-71655-4
Series ISSN
0724-6145
Edition Number
1
Number of Pages
VII, 254
Topics