Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

1. Front Matter

   Pages i-x

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2. The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

   • Mona Alidadi, Amirhossein Sahebkar, Saeid Eslami, Farveh Vakilian, Lida Jarahi, Maryam Alinezhad-Namaghi et al.

   Pages 1-11

3. Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer

   • Abolfazl Amini, Parand Khadivar, Ali Ahmadnia, Morteza Alipour, Muhammed Majeed, Tannaz Jamialahmadi et al.

   Pages 13-23

4. The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial

   • Seyed Reza Mirhafez, Mohsen Azimi-Nezhad, Maryam Dehabeh, Mitra Hariri, Ronika Danesh Naderan, Ali Movahedi et al.

   Pages 25-35

5. Protective Effects of Curcumin Phytosomes Against High-Fat Diet-Induced Atherosclerosis

   • Mahdi Hatamipour, Tannaz Jamialahmadi, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Luis E. Simental-Mendía, Mohammad Reza Sarborji et al.

   Pages 37-44

6. Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-Fed Rabbits

   • Amir Abbas Momtazi-Borojeni, Narges Amel Zabihi, Ramin Khameneh Bagheri, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar

   Pages 45-54

7. Updated Review on the Role of Curcumin in Gastrointestinal Cancers

   • Melika Naji, Setareh Soroudi, Maryam Akaberi, Amirhossein Sahebkar, Seyed Ahmad Emami

   Pages 55-89

8. Curcumin Can Bind and Interact with CRP: An in silico Study

   • Neda Shakour, Ricardo Cabezas, Janneth González Santos, George E. Barreto, Tannaz Jamialahmadi, Farzin Hadizadeh et al.

   Pages 91-100

9. Antifungal Activities of Curcuminoids and Difluorinated Curcumin Against Clinical Dermatophyte Isolates

   • Hossein Zarrinfar, Mahsa Behnam, Mahdi Hatamipour, Amirhossein Sahebkar

   Pages 101-107

10. Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial

    • Seyed Mojtaba Sohrevardi, Behrooz Heydari, Mahmoud Reza Azarpazhooh, Mohammad Teymourzadeh, Luis E. Simental-Mendía, Stephen L. Atkin et al.

    Pages 109-117

11. Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial

    • Yunes Panahi, Ashraf Karbasi, Ghasem Valizadegan, Nayyereh Ostadzadeh, Sara Saffar Soflaei, Tannaz Jamialahmadi et al.

    Pages 119-126

12. Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

    • Zinat Heidari, Marzieh Mohammadi, Amirhossein Sahebkar

    Pages 127-136

13. Paving the Road Toward Exploiting the Therapeutic Effects of Ginsenosides: An Emphasis on Autophagy and Endoplasmic Reticulum Stress

    • Milad Ashrafizadeh, Shima Tavakol, Reza Mohammadinejad, Zahra Ahmadi, Habib Yaribeygi, Tannaz Jamialahmadi et al.

    Pages 137-160

14. Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review

    • Atena Mahdavi, Mohammad Bagherniya, Mohammad Sadegh Mirenayat, Stephen L. Atkin, Amirhossein Sahebkar

    Pages 161-183

15. Plants with Anti-Addictive Potential

    • Eduardo Luis Konrath, Marcelo Dutra Arbo, Bruno Dutra Arbo, Mariana Appel Hort, Elaine Elisabetsky, Mirna Bainy Leal

    Pages 185-215

16. Use of Plant-Derived Natural Products in Sleep Disturbances

    • Diana Lelli, Livio Cortese, Claudio Pedone

    Pages 217-224

17. The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review

    • Fateme Gharibpour, Farinaz Shirban, Mohammad Bagherniya, Mohsen Nosouhian, Thozhukat Sathyapalan, Amirhossein Sahebkar

    Pages 225-248

18. Pharmacological Properties of the Plant-Derived Natural products Cannabinoids and Implications for Cardiovascular Health

    • Luca Liberale, Fabrizio Montecucco, Federico Carbone

    Pages 249-255

19. Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease

    • Luis E. Simental-Mendía, Claudia I. Gamboa-Gómez, Fernando Guerrero-Romero, Mario Simental-Mendía, Adriana Sánchez-García, Mariana Rodríguez-Ramírez

    Pages 257-272

20. Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats

    • Habib Yaribeygi, Stephen L. Atkin, George E. Barreto, Amirhossein Sahebkar

    Pages 273-281

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

• Curcumin
• Pharmacology
• Phytomedicine
• Complementary therapy
• Turmeric

• Department of Biological Sciences, University of Limerick, Limerick, Ireland

  George E. Barreto

• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

  Amirhossein Sahebkar

George E. Barreto earned his PhD in Neuroscience (2009) from Universidad Complutense Madrid (Spain) studying the effects of neurosteroids on reactive glia with aging. His post-doctoral training at Stanford University School of Medicine (2009-2011) focused on addressing the role of astrocytes activation following stroke and enhance astrocytic functions targeting neuronal protection. Dr. Barreto is currently a Lecturer in Cell Biology/Immunology at University of Limerick, Ireland. His research interests focus on deciphering the neuropathological mechanisms induced by accumulation of lipids in glial cells, identifying different mechanisms by which hormones can affect brain lipid metabolism and how lipids accumulation can induce neuroinflammation in absence of brain-synthesized estradiol. He is also interested in immune and neuroendocrine aspects of glial cells as a pathological mechanism in many neurological diseases. He has published over 200 peer-reviewed manuscripts, 12 book chapters,and participated as speaker in several international congresses/meetings.

Amirhossein Sahebkar received her Pharm.D and PhD (in Pharmaceutical Biotechnology) degrees from the Mashhad University of Medical Sciences (MUMS; Mashhad, Iran), and is currently serving as a faculty member at the Department of Medical Biotechnology (School of Medicine), and Biotechnology Research Center of MUMS, with an adjunct title at the Metabolic Research Centre, University of Western Australia (Perth, Australia). His research focuses on the investigation of novel lipid-modifying agents, including natural products, for the management of severe dyslipidemias (including familial hypercholesterolemia) and atherosclerotic cardiovascular disease. He has published over 800 publications on peer-reviewed international scientific journals, wrote several books and book chapters and presented numerous communications in international and national congresses. He is among ESI-listed top 1% of the world highly cited researchers in two fields: Pharmacology & Toxicology and Clinical Medicine. He is also a member of several national and international scientific committees and organizations.

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