Thyroid Cancer

1. Front Matter

   Pages i-xvii

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2. Differentiated Thyroid Cancer: Initial Management

   1. Front Matter

      Pages 1-1

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   2. A Patient with a Single Thyroid Nodule Suspicious for Follicular Neoplasm According to the Bethesda System for Reporting Thyroid Cytopathology: Molecular Evaluation

      • Dimpi Desai, Susan J. Mandel

      Pages 3-12

   3. A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer

      • Giorgio Grani, Valeria Ramundo, Cosimo Durante

      Pages 13-17

   4. A Case of a Small (1–2 cm) Papillary Thyroid Cancer in a Young Patient: Lobectomy Versus Total Thyroidectomy

      • Gerard M. Doherty

      Pages 19-24

   5. A Patient with Papillary Microcarcinoma Undergoing Active Surveillance

      • Laura Boucai

      Pages 25-33

   6. Completion Thyroidectomy in a Patient with Low-Risk Papillary Cancer

      • David S. Cooper

      Pages 35-40

   7. Papillary Thyroid Cancer with Microscopic Extra-thyroidal Extension

      • Donald S. A. McLeod

      Pages 41-53

   8. A Small Papillary Thyroid Cancer with Angioinvasion

      • Michael E. Hopkins, Iain J. Nixon

      Pages 55-58

   9. A Patient with a Pathological Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)

      • David Carruthers, Steven P. Hodak

      Pages 59-67

   10. Papillary Thyroid Cancer with Central Neck Lymph Node Metastases

       • Alyse S. Goldberg, Lorne E. Rotstein, Anna M. Sawka

       Pages 69-80

   11. A Patient with a Large Minimally Invasive Follicular Thyroid Cancer

       • Jina Kim, Wen T. Shen, Julie Ann Sosa

       Pages 81-92

   12. An Adolescent with Papillary Thyroid Carcinoma and Locally Metastatic Disease but No Distant Metastases

       • Sarah J. Bottomley, Steven G. Waguespack

       Pages 93-102

3. Differentiated Thyroid Cancer: Postoperative Follow-Up

   1. Front Matter

      Pages 103-103

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   2. A Patient with Papillary Thyroid Cancer and Biochemical Evidence of Possible Residual Disease at the One-Year Follow-Up Visit

      • Valeria Ramundo, Sebastiano Filetti, Cosimo Durante

      Pages 105-112

   3. A Patient with Low-Risk Papillary Thyroid Cancer Who Has Undergone a Lobectomy: Monitoring for Recurrent Disease and Assessment of Thyroid Function

      • Fernanda Vaisman, Marcela Vaisberg Cohen

      Pages 113-117

   4. A Patient with Papillary Thyroid Carcinoma and Biochemical Evidence of Disease at Follow-Up Visits and Increasing Serum Tg Values at Follow-Up Assessments

      • Yasuhiro Ito, Akira Miyauchi

      Pages 119-129

   5. A Young Patient with Recurrent Lymph Node Involvement: Imaging, Cytology, and Thyroglobulin Washout

      • Valeria Ramundo, Sebastiano Filetti, Cosimo Durante

      Pages 131-138

4. Differentiated Thyroid Cancer: Special Issues

   1. Front Matter

      Pages 139-139

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   2. Papillary Thyroid Carcinoma Diagnosed During Pregnancy

      • Zachary Simons, David S. Cooper

      Pages 141-145

Now in its second edition utilizing brand new clinical case material, this popular, user-friendly text presents the diagnosis and treatment of thyroid cancer and related clinical issues, providing clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various manifestations of thyroid cancer that they may encounter. Each chapter is a case report that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature. 


Written by experts in the field, these cases illustrate treatment for both low- and high-risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer and anaplastic thyroid cancer. Topics new to the second edition include information on management of small thyroid cancers with “active surveillance” (without surgery), new chemotherapeutic approaches to advanced thyroid cancer, and new information on a lesion that is no longer considered to be thyroid cancer (Neoplastic Follicular Thyroid Neoplasm with Papillary-Like Features [NIFTP]), as well as material on external beam radiotherapy and new approaches to the management of anaplastic thyroid cancer.


Pragmatic and reader-friendly, this second edition of Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike.

• Active surveillance
• Anaplastic thyroid cancer
• C cell hyperplasia
• Differentiated thyroid cancer
• Follicular thyroid cancer
• Hũrthle cell carcinoma
• Medullary thyroid cancer
• Neoplastic follicular thyroid neoplasm papillary-like features
• Nodal metastases
• Nodular thyroid disease
• Papillary thyroid cancer
• Radioactive iodine therapy
• Thyroid cancer
• Thyroid nodules
• Thyroidectomy
• Tyrosine kinase inhibitor treatment

• Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

  Giorgio Grani, Cosimo Durante

• Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, USA

  David S. Cooper

Giorgio Grani, MD, PhD, Assistant Professor of Internal Medicine, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

David S. Cooper, MD, Professor of Medicine and Radiology, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Cosimo Durante, MD, Associate Professor of Internal Medicine, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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