Advances in Experimental Medicine and Biology

Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases

Editors: Lizard, Gérard (Ed.)

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  • Introduces the reader to peroxisomal biology and biogenesis
  • Discusses the role of peroxisomes in peroxisomal biogenesis disorders including Zellweger and Heimler Syndrome
  • Highlights the contribution of peroxisomes to neurodegenerative diseases such as Alzheimer's and Multiple Sclerosis
  • Provides an overview of cell and animal models for studying the role of peroxisomes in human diseases
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  • ISBN 978-3-030-60204-8
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About this book

This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases.

It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation.  The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment.

This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.

About the authors

Gérard LIZARD is currently Inserm Scientist and Director of the laboratory Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism since 2012 at the Université de Bourgogne (Dijon, France); biochemistry Engineer (National Institute of Applied Sciences (INSA), Lyon, France); PhD - Cellular and Molecular Biology (Lyon, France); PhD - Human Biology / Immunology; Competency for Research Direction (Lyon, France); After seven years of post-doctoral position in Pharmaceutical companies as researcher (1984-1991), he has been recruited by Inserm in 1991; currently senior research fellow Inserm, and director of the team ‘Biochemistry of the peroxisome, inflammation and lipid metabolism’. He managed 20 masters and 21 PhD Theses. He has an expertise in lipids (cholesterol, oxysterols, fatty acids), organelles (peroxisome, mitochondria, lysosome) cell death (apoptosis, autophagy), oxidative stress, inflammation, pharmacology (with a great interest for natural compounds), neurobiology and nanotechnology (targeted therapy). He contributed to several clinical studies as principal and associated investigator.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Peroxisome: Metabolic Functions and Biogenesis

    Pages 3-17

    Okumoto, Kanji (et al.)

  • Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk

    Pages 19-30

    Fransen, Marc (et al.)

  • 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration

    Pages 31-41

    Nury, Thomas (et al.)

  • Peroxisome Biogenesis Disorders

    Pages 45-54

    Honsho, Masanori (et al.)

  • Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles and Peroxisomal Disorders

    Pages 55-70

    Wanders, Ronald J. A. (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-3-030-60204-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-030-60203-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases
Editors
  • Gérard Lizard
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1299
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-60204-8
DOI
10.1007/978-3-030-60204-8
Hardcover ISBN
978-3-030-60203-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 212
Number of Illustrations
6 b/w illustrations, 38 illustrations in colour
Topics