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Clinical Xenotransplantation

Pathways and Progress in the Transplantation of Organs and Tissues Between Species

  • Book
  • © 2020

Overview

Editors:
  1. David K. C. Cooper

    1. Xenotransplantation Program, University of Alabama at Birmingham, Birmingham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Guerard Byrne

    1. Department of Surgery, University of Alabama at Birmingham, Birmingham, USA

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    You can also search for this editor in PubMed   Google Scholar

  • First title of its kind that provides up-to-date information on the planning and preparation that goes toward clinical xenotransplantation
  • Features an authorship consisting of several leaders in the field of clinical organ transplantation as well as the leaders in the field of xenotransplantation research
  • Reviews and analyzes the research that has provided the recent experimental advances within the field

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xxix
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  2. Clinical and Experimental Xenotransplantation: Background

    1. Front Matter

      Pages 1-1
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    2. A Brief History of Clinical Cross-Species Organ Xenotransplantation

      • David K. C. Cooper
      Pages 3-26

    3. The Pathobiology of Pig-to-Primate Xeno.: A Historical Review

      • David K. C. Cooper, Mohamed B. Ezzelarab, Hidetaka Hara, Hayato Iwase, Whayoung Lee, Martin Wijkstrom et al.
      Pages 27-63

    4. Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?

      • Qi Li, Hidetaka Hara, Zhongqiang Zhang, Michael E. Breimer, Yi Wang, David K. C. Cooper
      Pages 65-78

    5. Sensitization to Human Leukocyte Antigens and Xenotransplantation

      • Guerard Byrne
      Pages 79-87

  3. Pig Kidney and Heart Xenotransplantation in Nonhuman Primates: The Present Position

    1. Front Matter

      Pages 89-89
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    2. Kidney Xenotransplantation in Nonhuman Primates

      • David K. C. Cooper, Hidetaka Hara, Hayato Iwase, Takayuki Yamamoto, Abhijit Jagdale, Douglas J. Anderson et al.
      Pages 91-106

    3. Cardiac Xenotransplantation in Nonhuman Primates

      • David K. C. Cooper
      Pages 107-117

  4. Organ-Source Pig Genetic Engineering and Regulation

    1. Front Matter

      Pages 119-119
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    2. Gene-edited Pigs for Xenotransplantation

      • Willard Eyestone, Kent Adams, Suyapa Ball, John Bianchi, Steve Butler, Amy Dandro et al.
      Pages 121-140

    3. Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Design and Pathogen Prevention

      • Karl Kraebber, Edward Gray
      Pages 141-153

  5. Antibody-Mediated Allotransplant Rejection: Lessons for Xenotransplantation

    1. Front Matter

      Pages 155-155
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    2. Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection

      • Stuart J. Knechtle, Jean Kwun, Brendon Lovasik, Alton B. Farris, A. Joseph Tector, Andrew B. Adams
      Pages 157-164

    3. Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejection

      • Robert A. Montgomery
      Pages 165-175

    4. Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejection

      • Stanley C. Jordan, Noriko Ammerman, Ashley Vo
      Pages 177-189

    5. Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newborn

      • Jeffrey L. Platt, Marilia Cascalho
      Pages 191-201

  6. Patient Evaluation and Selection for First Clinical Trials of Kidney or Heart Xenotransplantation

    1. Front Matter

      Pages 203-203
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    2. Defining an “Acceptable Risk Threshold”: Who Should Be the First Kidney Xenotransplant Recipient?

      • Jayme E. Locke
      Pages 205-207

    3. Selection of Patients for the Initial Clinical Trials of Kidney Xenotransplantation

      • David K. C. Cooper, Abhijit Jagdale, Roslynn B. Mannon, Vineeta Kumar, Robert Gaston, Michael J. Hanaway et al.
      Pages 209-220
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Keywords

About this book

This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year.  Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made.  Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation.  


The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. 


A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.



Editors and Affiliations

  • Xenotransplantation Program, University of Alabama at Birmingham, Birmingham, USA

    David K. C. Cooper

  • Department of Surgery, University of Alabama at Birmingham, Birmingham, USA

    Guerard Byrne

About the editors

David K.C. Cooper MD, PhD, FRCS
University of Alabama at Birmingham (UAB)
Co-Director, Xenotransplantation Program
Department of Surgery
Birmingham, AL 


Guerard W. Byrne, PhD
Department of Surgery
University of Alabama at Birmingham
Birmingham, AL
USA




Bibliographic Information

  • Book Title: Clinical Xenotransplantation

  • Book Subtitle: Pathways and Progress in the Transplantation of Organs and Tissues Between Species

  • Editors: David K. C. Cooper, Guerard Byrne

  • DOI: https://doi.org/10.1007/978-3-030-49127-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-49126-0Published: 09 September 2020

  • Softcover ISBN: 978-3-030-49129-1Published: 10 September 2021

  • eBook ISBN: 978-3-030-49127-7Published: 08 September 2020

  • Edition Number: 1

  • Number of Pages: XXIX, 306

  • Number of Illustrations: 23 b/w illustrations, 59 illustrations in colour

  • Topics: Surgery, Hepatology, Microbiology, Immunology

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