Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers

1. Front Matter

   Pages i-xi

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2. Role of Specific Phytochemicals Against Gastrointestinal Malignancies

   • Dariya Begum, Neha Merchant, Ganji Purnachandra Nagaraju

   Pages 1-33

3. Role of Phytochemicals on Growth and Metastasis of GI Cancer

   • Krishnamurthy Nakuluri, Gowru Srivani

   Pages 35-50

4. Cancer Stem Cells as Therapeutic Targets for Gastrointestinal Cancers

   • Jyothi Priya Mandala, Srinivas Pittala, Gowru Srivani

   Pages 51-81

5. Phytochemicals Plus Checkpoint Inhibitors in GI Cancers

   • Krishnamurthy Nakuluri, Gowru Srivani

   Pages 83-107

6. Crucial Role of Curcumin in Gut Microbiota Associated with GI Cancers

   • Santoshi Muppala, Siva Krishna Prasad Konduru

   Pages 109-117

7. Cellular and Molecular Mechanisms of Garlic Compounds in Common GI Cancers

   • Rama Rao Malla

   Pages 119-139

8. Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy

   • Harshvardhan Chauhan, Masood Alam

   Pages 141-167

9. Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer

   • Asad ur Rahman, Deepika Sarvepalli, Mamoon Ur Rashid, Saeed Ali, Awais Naeem, Asif Imran et al.

   Pages 169-187

10. Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors

    • Muzammil Muhammad Khan, Deepika Sarvepalli, Mamoon Ur Rashid, Hammad Zafar, Muhammad Shayan Khan, Effa Zahid et al.

    Pages 189-208

11. Therapeutic Effects of Curcumin Against Colorectal Cancer

    • Christoffer Briggs Lambring, Sagar Shelake, Faraz Hasan, Riyaz Basha

    Pages 209-222

12. Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes

    • Bayarmaa Mandzhieva, Rima Shobar, Anum Jalil, Hammad Zafar, Mamoon Ur Rashid, Ranjeet Kumar et al.

    Pages 223-260

13. Role of Dietary Supplementation of Natural Products in the Prevention and Treatment of Liver Diseases

    • Sathish Kumar Mungamuri, Yamini Javvadi

    Pages 261-285

14. Emerging Roles of Phytochemicals in Hepatocellular Carcinoma

    • Hammad Zafar, Mamoon Ur Rashid, Deepika Sarvepalli, Muzammil Muhammad Khan, Bayarmaa Mandzhieva, Akriti Gupta Jain et al.

    Pages 287-302

15. Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma

    • Austin Cook, Shadab A. Siddiqi

    Pages 303-329

16. Back Matter

    Pages 331-340

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Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy.  The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance.

To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

• malignancies
• chemoradiation
• chemoradioresistance
• chemotherapeutic
• phytochemicals
• cell death
• checkpoint inhibitors
• metastasis
• therapeutic drugs
• preventative medicine
• personalized care
• cancer resistance
• exosomes
• nanotechnology
• clinicians
• gastrointestinal
• anticancer

• Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, USA

  Ganji Purnachandra Nagaraju

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his MSc and PhD, both in biotechnology from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his D.Sc. from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju's research focuses on translational research in gastrointestinal malignancies. He has published over 90 research papers in highly respected international journals and has presented more than 50 abstracts at various national and international conferences. He is author and editor of several books. Dr. Nagaraju is an editorial board member of several internationally recognized academic journals, and is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society and the American Association of Cancer Research (AACR). 

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