CYBER DEAL: 50% off all Springer eBooks | Get this offer!

Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers

Editors: Nagaraju, Ganji Purnachandra (Ed.)

Free Preview
  • Focuses on the current broad range of treatment options and prospective treatments for GI cancers
  • Provides an understanding of the roadblocks of chemotherapy for newly-diagnosed patients and patients with metastatic GI cancers
  • Gives an overview on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and signaling pathways
see more benefits

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-3-030-48405-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
About this book

Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy.  The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance.

To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

About the authors

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his MSc and PhD, both in biotechnology from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his D.Sc. from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju's research focuses on translational research in gastrointestinal malignancies. He has published over 90 research papers in highly respected international journals and has presented more than 50 abstracts at various national and international conferences. He is author and editor of several books. Dr. Nagaraju is an editorial board member of several internationally recognized academic journals, and is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society and the American Association of Cancer Research (AACR). 

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Role of Specific Phytochemicals Against Gastrointestinal Malignancies

    Pages 1-33

    Begum, Dariya (et al.)

  • Role of Phytochemicals on Growth and Metastasis of GI Cancer

    Pages 35-50

    Nakuluri, Krishnamurthy (et al.)

  • Cancer Stem Cells as Therapeutic Targets for Gastrointestinal Cancers

    Pages 51-81

    Mandala, Jyothi Priya (et al.)

  • Phytochemicals Plus Checkpoint Inhibitors in GI Cancers

    Pages 83-107

    Nakuluri, Krishnamurthy (et al.)

  • Crucial Role of Curcumin in Gut Microbiota Associated with GI Cancers

    Pages 109-117

    Muppala, Santoshi (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-3-030-48405-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
Editors
  • Ganji Purnachandra Nagaraju
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG
eBook ISBN
978-3-030-48405-7
DOI
10.1007/978-3-030-48405-7
Hardcover ISBN
978-3-030-48404-0
Edition Number
1
Number of Pages
XI, 340
Number of Illustrations
1 b/w illustrations, 21 illustrations in colour
Topics