Editors:
- Provides a comprehensive and up-to-date account of Nrf2 research
- Brings together mechanistic understanding and phenotypical/clinical knowledge about Nrf2
- Covers role of Nrf2 in the immune response during inflammation, inflammation-triggered carcinogenesis, neuroinflammation, atherosclerosis, metabolic diseases, and others
Part of the book series: Progress in Inflammation Research (PIR, volume 85)
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Table of contents (9 chapters)
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Front Matter
About this book
Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
Editors and Affiliations
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Department of Biology, University of Minnesota Duluth, Duluth, USA
Huai Deng
About the editor
Bibliographic Information
Book Title: Nrf2 and its Modulation in Inflammation
Editors: Huai Deng
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-030-44599-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-44597-3Published: 22 May 2020
eBook ISBN: 978-3-030-44599-7Published: 21 May 2020
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: IX, 205
Number of Illustrations: 39 b/w illustrations, 12 illustrations in colour
Topics: Immunology, Cell Physiology, Gene Expression, Oxidative Stress